哮喘患者中超声雾化蒸馏水与冷空气过度通气激发试验的比较。

Comparison of ultrasonically nebulized distilled water and cold-air hyperventilation challenges in asthmatic patients.

作者信息

Lemire T S, Hopp R J, Bewtra A K, Nair N M, Townley R G

机构信息

Allergic Disease Center, Creighton University, Omaha 68178.

出版信息

Chest. 1989 May;95(5):958-61. doi: 10.1378/chest.95.5.958.

DOI:10.1378/chest.95.5.958

PMID:2495907

Abstract

Cold-air hyperventilation (CAHC) and ultrasonically nebulized distilled water (UNDW) challenges were compared in 11 asthmatic patients who were moderately sensitive to methacholine. The challenges were performed on two separate days within one week of each other. Baseline FEV1 on each test day was greater than 70 percent of predicted. Ten of 11 subjects' FEV1 decreased at least 15 percent, and nine of 11 decreased at least 20 percent during the UNDW. Ten of 11 subjects' FEV1 decreased at least 10 percent, and eight of 11 decreased at least 15 percent during the CAHC. Using a Spearman rank coefficient, the results of the CAHC and UNDW were compared; the best correlation between the various CAHC and UNDW measurements equaled only 0.51. The correlation between UNDW and CAHC suggests that the mechanism of action of each challenge may be different.

摘要

对11名对乙酰甲胆碱中度敏感的哮喘患者进行了冷空气过度通气（CAHC）和超声雾化蒸馏水（UNDW）激发试验比较。激发试验在一周内的两个不同日期进行。每个测试日的基线第一秒用力呼气容积（FEV1）大于预测值的70%。在UNDW激发试验期间，11名受试者中有10名的FEV1下降至少15%，11名中有9名下降至少20%。在CAHC激发试验期间，11名受试者中有10名的FEV1下降至少10%，11名中有8名下降至少15%。使用斯皮尔曼等级系数对CAHC和UNDW的结果进行比较；各种CAHC和UNDW测量之间的最佳相关性仅为0.51。UNDW和CAHC之间的相关性表明，每种激发试验的作用机制可能不同。