Vyas Dinesh, Laput Gieric, Vyas Arpitak K
College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Onco Targets Ther. 2014 Jun 12;7:1015-23. doi: 10.2147/OTT.S60114. eCollection 2014.
The lack of therapy and the failure of existing therapy has been a challenge for clinicians in treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line therapy in various cancers; however, toxicity, resistance, and treatment failure limit their clinical use. Their status leads us to discover and investigate more targeted therapy with more efficacy. In this article, we dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory.
缺乏有效的治疗方法以及现有治疗手段的失败一直是临床医生在治疗各种癌症时面临的挑战。阿霉素、5-氟尿嘧啶、顺铂和紫杉醇是多种癌症的一线治疗药物；然而，毒性、耐药性和治疗失败限制了它们的临床应用。这种现状促使我们去发现和研究更具靶向性、疗效更佳的治疗方法。在本文中，我们从患者角度、肿瘤生物学角度、治疗诱导的转移以及实验室生成的细胞数据等方面剖析相关文献。
