• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

背侧耳蜗核的浅层星状细胞。

Superficial stellate cells of the dorsal cochlear nucleus.

机构信息

Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University Portland, OR, USA.

出版信息

Front Neural Circuits. 2014 Jun 10;8:63. doi: 10.3389/fncir.2014.00063. eCollection 2014.

DOI:10.3389/fncir.2014.00063
PMID:24959121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4051266/
Abstract

The dorsal cochlear nucleus (DCN) integrates auditory and multisensory signals at the earliest levels of auditory processing. Proposed roles for this region include sound localization in the vertical plane, head orientation to sounds of interest, and suppression of sensitivity to expected sounds. Auditory and non-auditory information streams to the DCN are refined by a remarkably complex array of inhibitory and excitatory interneurons, and the role of each cell type is gaining increasing attention. One inhibitory neuron that has been poorly appreciated to date is the superficial stellate cell. Here we review previous studies and describe new results that reveal the surprisingly rich interactions that this tiny interneuron has with its neighbors, interactions which enable it to respond to both multisensory and auditory afferents.

摘要

背侧耳蜗核(DCN)在听觉处理的最早阶段整合听觉和多感觉信号。该区域的建议作用包括在垂直平面上定位声音、将头部定向到感兴趣的声音以及抑制对预期声音的敏感性。听觉和非听觉信息流到 DCN 被一系列非常复杂的抑制性和兴奋性中间神经元进行了细化,并且每种细胞类型的作用都越来越受到关注。迄今为止,一种被低估的抑制性神经元是浅层星状细胞。在这里,我们回顾了以前的研究,并描述了新的结果,这些结果揭示了这个微小的中间神经元与其邻居之间惊人丰富的相互作用,这些相互作用使其能够对多感觉和听觉传入做出反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/0123349aefd5/fncir-08-00063-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/77726adfcde4/fncir-08-00063-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/6e4362ae1629/fncir-08-00063-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/62ab55f10db6/fncir-08-00063-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/736a8afd6834/fncir-08-00063-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/614c8bd72f01/fncir-08-00063-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/0123349aefd5/fncir-08-00063-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/77726adfcde4/fncir-08-00063-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/6e4362ae1629/fncir-08-00063-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/62ab55f10db6/fncir-08-00063-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/736a8afd6834/fncir-08-00063-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/614c8bd72f01/fncir-08-00063-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/4051266/0123349aefd5/fncir-08-00063-g0006.jpg

相似文献

1
Superficial stellate cells of the dorsal cochlear nucleus.背侧耳蜗核的浅层星状细胞。
Front Neural Circuits. 2014 Jun 10;8:63. doi: 10.3389/fncir.2014.00063. eCollection 2014.
2
Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.化学性突触传递到小鼠耳蜗背核浅层星状细胞。
J Neurophysiol. 2014 May;111(9):1812-22. doi: 10.1152/jn.00821.2013. Epub 2014 Feb 12.
3
Contralateral effects and binaural interactions in dorsal cochlear nucleus.耳蜗背侧核中的对侧效应和双耳相互作用。
J Assoc Res Otolaryngol. 2005 Sep;6(3):280-96. doi: 10.1007/s10162-005-0008-5.
4
The multiple functions of T stellate/multipolar/chopper cells in the ventral cochlear nucleus.T 星状/多极/切断细胞在耳蜗腹核中的多重功能。
Hear Res. 2011 Jun;276(1-2):61-9. doi: 10.1016/j.heares.2010.10.018. Epub 2010 Nov 4.
5
Descending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus.来自下丘的下行轴突投射到耳蜗背核的几乎所有兴奋性和抑制性细胞类型。
J Neurosci. 2022 Apr 20;42(16):3381-3393. doi: 10.1523/JNEUROSCI.1190-21.2022. Epub 2022 Mar 10.
6
Synaptic inputs to stellate cells in the ventral cochlear nucleus.耳蜗腹侧核中星状细胞的突触输入。
J Neurophysiol. 1998 Jan;79(1):51-63. doi: 10.1152/jn.1998.79.1.51.
7
Multisensory activation of ventral cochlear nucleus D-stellate cells modulates dorsal cochlear nucleus principal cell spatial coding.腹侧耳蜗核 D 星状细胞的多感觉激活调节背侧耳蜗核主要细胞的空间编码。
J Physiol. 2018 Sep;596(18):4537-4548. doi: 10.1113/JP276280. Epub 2018 Aug 18.
8
Onset neurones in the anteroventral cochlear nucleus project to the dorsal cochlear nucleus.前腹侧蜗神经核中的起始神经元投射至背侧蜗神经核。
J Assoc Res Otolaryngol. 2004 Jun;5(2):153-70. doi: 10.1007/s10162-003-4036-8.
9
Cell-type specific short-term plasticity at auditory nerve synapses controls feed-forward inhibition in the dorsal cochlear nucleus.听觉神经突触处的细胞类型特异性短期可塑性控制着耳蜗背侧核中的前馈抑制。
Front Neural Circuits. 2014 Jul 4;8:78. doi: 10.3389/fncir.2014.00078. eCollection 2014.
10
Pharmacological evidence of inhibitory and disinhibitory neuronal circuits in dorsal cochlear nucleus.耳蜗背侧核中抑制性和去抑制性神经回路的药理学证据。
J Neurophysiol. 2000 Feb;83(2):926-40. doi: 10.1152/jn.2000.83.2.926.

引用本文的文献

1
Identification and quantification of GABA R-α1-positive cells in the DCN of rats with behavioral evidence of noise-induced tinnitus.对有噪声性耳鸣行为证据的大鼠的背侧耳蜗核中GABA R-α1阳性细胞进行鉴定和定量分析。
IBRO Neurosci Rep. 2025 Jul 16;19:332-344. doi: 10.1016/j.ibneur.2025.07.005. eCollection 2025 Dec.
2
A comprehensive review of HCN channel expression and I in the auditory system: then, now, and future perspectives.对听觉系统中HCN通道表达及电流的全面综述:过去、现在与未来展望。
J Neurophysiol. 2025 Aug 1;134(2):458-470. doi: 10.1152/jn.00602.2024. Epub 2025 Jul 7.
3
Connexin36 RNA Expression in the Cochlear Nucleus of the Echolocating Bat, Eptesicus fuscus.

本文引用的文献

1
Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus.主导细胞亚阈突触电位对耳蜗背核中间神经元放电的控制。
Neuron. 2014 Jul 16;83(2):324-330. doi: 10.1016/j.neuron.2014.06.008. Epub 2014 Jul 4.
2
Structured connectivity in cerebellar inhibitory networks.小脑抑制性网络的结构连接。
Neuron. 2014 Feb 19;81(4):913-29. doi: 10.1016/j.neuron.2013.12.029.
3
Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.化学性突触传递到小鼠耳蜗背核浅层星状细胞。
回声定位蝙蝠,棕蝠耳蜗核中连接蛋白 36 RNA 的表达。
J Assoc Res Otolaryngol. 2023 Jun;24(3):281-290. doi: 10.1007/s10162-023-00898-y. Epub 2023 May 30.
4
Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum.关注红藻氨酸受体在耳蜗背核(DCN)和小脑中的新兴作用。
Int J Mol Sci. 2023 Jan 15;24(2):1718. doi: 10.3390/ijms24021718.
5
Mobile zinc as a modulator of sensory perception.移动锌作为感觉感知的调节剂。
FEBS Lett. 2023 Jan;597(1):151-165. doi: 10.1002/1873-3468.14544. Epub 2022 Dec 20.
6
Sparsely Distributed, Pre-synaptic Kv3 K Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit.稀疏分布的突触前Kv3钾通道通过调节听觉脑干回路中的突触噪声来控制自发放电和跨单元同步。
Front Cell Neurosci. 2021 Sep 3;15:721371. doi: 10.3389/fncel.2021.721371. eCollection 2021.
7
Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis.成年小鼠耳蜗核神经元的分类:线性判别分析。
PLoS One. 2019 Oct 3;14(10):e0223137. doi: 10.1371/journal.pone.0223137. eCollection 2019.
8
Auditory Golgi cells are interconnected predominantly by electrical synapses.听觉高尔基细胞主要通过电突触相互连接。
J Neurophysiol. 2016 Aug 1;116(2):540-51. doi: 10.1152/jn.01108.2015. Epub 2016 Apr 27.
9
AMPA receptor inhibition by synaptically released zinc.突触释放的锌对α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)受体的抑制作用
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15749-54. doi: 10.1073/pnas.1512296112. Epub 2015 Dec 8.
10
Editorial: Inhibitory function in auditory processing.社论:听觉处理中的抑制功能。
Front Neural Circuits. 2015 Sep 1;9:45. doi: 10.3389/fncir.2015.00045. eCollection 2015.
J Neurophysiol. 2014 May;111(9):1812-22. doi: 10.1152/jn.00821.2013. Epub 2014 Feb 12.
4
Regulation of interneuron excitability by gap junction coupling with principal cells.缝隙连接耦联与主细胞调节中间神经元兴奋性。
Nat Neurosci. 2013 Dec;16(12):1764-72. doi: 10.1038/nn.3569. Epub 2013 Nov 3.
5
Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum.小脑内单个平行纤维-分子层中间神经元突触的 extrasynaptic NMDAR 的激活。
J Neurosci. 2013 Oct 9;33(41):16323-33. doi: 10.1523/JNEUROSCI.1971-13.2013.
6
Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.混合 Glycine/GABA 突触中囊泡递质内容物的快速、非活动依赖性翻转。
J Neurosci. 2013 Mar 13;33(11):4768-81. doi: 10.1523/JNEUROSCI.5555-12.2013.
7
Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons.内向整流钾电流的不同水平在一群耳蜗背核锥体神经元中产生异质性的神经元行为。
J Neurophysiol. 2012 Jun;107(11):3008-19. doi: 10.1152/jn.00660.2011. Epub 2012 Feb 29.
8
The sound of silence: ionic mechanisms encoding sound termination.寂静之声:编码声音终止的离子机制。
Neuron. 2011 Sep 8;71(5):911-25. doi: 10.1016/j.neuron.2011.06.028.
9
Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition.有耳鸣行为证据的小鼠由于 GABA 能抑制作用减弱而表现出耳蜗背核过度兴奋。
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7601-6. doi: 10.1073/pnas.1100223108. Epub 2011 Apr 18.
10
Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input.具有稀疏兴奋性突触输入的电耦合中间神经元网络的快速去同步。
Neuron. 2010 Aug 12;67(3):435-51. doi: 10.1016/j.neuron.2010.06.028.