School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea ; Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea ; Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Evid Based Complement Alternat Med. 2014;2014:703624. doi: 10.1155/2014/703624. Epub 2014 May 14.
Mistletoe (Viscum Album coloratum) has been known as a medicinal plant in European and Asian countries. Recent data show that biological activity of mistletoe alleviates hypertension, heart disease, renal failure, and cancer development. In this study, we report the antidiabetic effect of Korean mistletoe extract (KME). KME treatments enhanced the insulin secretion from the pancreatic β -cell without any effects of cytotoxicity. PDX-1 and beta2/neuroD known as transcription factors that regulate the expression of insulin gene were upregulated by treatment of the KME protein fractions isolated by ion-exchange chromatography after ammonium sulfate precipitation. Furthermore, these KME protein fractions significantly lowered the blood glucose level and the volume of drinking water in alloxan induced hyperglycemic mice. Taken together with the findings, it provides new insight that KME might be served as a useful source for the development of medicinal reagent to reduce blood glucose level of type I diabetic patients.
槲寄生（Viscum Album coloratum）在欧洲和亚洲国家一直被用作药用植物。最近的数据表明，槲寄生的生物活性可以缓解高血压、心脏病、肾衰竭和癌症的发展。在这项研究中，我们报告了韩国槲寄生提取物（KME）的降血糖作用。KME 处理增强了胰腺β细胞的胰岛素分泌，而没有任何细胞毒性作用。PDX-1 和 beta2/neuroD 作为调节胰岛素基因表达的转录因子，在用离子交换色谱法分离硫酸铵沉淀后的 KME 蛋白级分处理后上调。此外，这些 KME 蛋白级分可显著降低链脲佐菌素诱导的高血糖小鼠的血糖水平和饮水量。总的来说，这些发现提供了新的见解，即 KME 可能成为开发降低 I 型糖尿病患者血糖水平的药用试剂的有用来源。
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