Maruo Takashi, Fujimoto Yasushi, Yoshida Kenji, Hiramatsu Mariko, Suzuki Atsushi, Nishio Naoki, Shimono Mariko, Nakashima Tsutomu
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Oncol Lett. 2014 Jul;8(1):335-338. doi: 10.3892/ol.2014.2137. Epub 2014 May 12.
Lymph node metastasis is a major prognostic factor in parotid carcinoma, however, the pre-operative diagnosis of occult nodal metastasis is difficult in clinical N0 (cN0) parotid cancer patients. In addition, the indication of neck dissection in T1-3 cN0 patients is controversial. The current study investigated 17 patients with clinical T1-3 cN0 parotid cancer, and analyzed the correlation between patient symptoms/findings and pathological N status/tumor histological grade. In the statistical analysis, pain was found to significantly correlate with neck metastasis. Furthermore, cN0-staged patients without pain exhibited no neck metastasis. However, no significant correlation was identified between patient symptoms or findings and histological grade. These results indicate the possibility that selective neck dissection can be omitted for T1-3 cN0-staged patients without pain.
淋巴结转移是腮腺癌的一个主要预后因素，然而，对于临床N0（cN0）腮腺癌患者，术前隐匿性淋巴结转移的诊断较为困难。此外，T1-3 cN0患者行颈部清扫术的指征也存在争议。本研究调查了17例临床T1-3 cN0腮腺癌患者，并分析了患者症状/体征与病理N状态/肿瘤组织学分级之间的相关性。在统计分析中，发现疼痛与颈部转移显著相关。此外，无疼痛的cN0分期患者未出现颈部转移。然而，未发现患者症状或体征与组织学分级之间存在显著相关性。这些结果表明，对于无疼痛的T1-3 cN0分期患者，有可能省略选择性颈部清扫术。
