Donato Giuseppe, Conforti Francesco, Camastra Caterina, Ammendola Michele, Donato Annalidia, Renzulli Attilio
Department of Pathology, School of Medicine, University Magna Graecia, Catanzaro I-88100, Italy.
Department of Pharmacology, School of Medicine, University Magna Graecia, Catanzaro I-88100, Italy.
Oncol Lett. 2014 Jul;8(1):379-383. doi: 10.3892/ol.2014.2104. Epub 2014 Apr 29.
A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endothelial phenotype; however, its histogenesis remains unclear. Currently, no available studies have correlated the pathological characteristics of cardiac myxomas, such as cell differentiation and vascularization, with the angiogenic factors of mast cells. The aim of the present study was to investigate the role of mast cell tryptases on the development of cardiac myxomas and examine the histogenesis of tumoral cells. A series of 10 cardiac myxomas were examined by immunohistochemical analysis for the presence of tryptase-positive mast cells. Statistical analysis of our data demonstrated that angiogenesis and the development of pseudovascular structures were correlated with the number of tryptase-positive mast cells. Therefore, we hypothesize that cardiac myxoma cells are endothelial precursors which are able to generate mature vascular structures. Further morphological and immunophenotypic analyses of tumoral cells may corroborate such a hypothesis.
许多现有研究将肥大细胞及其血管生成因子（如类胰蛋白酶表达）在癌症生长中的作用作为主要研究目标。心脏黏液瘤是一种罕见的肿瘤，是心脏最常见的原发性肿瘤。心脏黏液瘤的细胞成分具有内皮细胞表型，但其组织发生仍不清楚。目前，尚无研究将心脏黏液瘤的病理特征（如细胞分化和血管形成）与肥大细胞的血管生成因子联系起来。本研究的目的是探讨肥大细胞类胰蛋白酶在心脏黏液瘤发生发展中的作用，并研究肿瘤细胞的组织发生。通过免疫组织化学分析，对10例心脏黏液瘤进行检测，以确定类胰蛋白酶阳性肥大细胞的存在情况。对我们的数据进行统计分析表明，血管生成和假血管结构的形成与类胰蛋白酶阳性肥大细胞的数量相关。因此，我们推测心脏黏液瘤细胞是能够生成成熟血管结构的内皮前体细胞。对肿瘤细胞进行进一步的形态学和免疫表型分析可能会证实这一假设。
