Xuan Wei-Xia, Zhang Jian-Chu, Zhou Qiong, Yang Wei-Bing, Ma Li-Jun
Department of Respiratory and Critical Medicine, The People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
Department of Respiratory Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Oncol Lett. 2014 Jul;8(1):449-453. doi: 10.3892/ol.2014.2109. Epub 2014 May 2.
Tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs) are difficult to differentiate between in certain clinical situations. Interleukin (IL)-33 is a cytokine that participates in inflammatory responses and may have a role in pleural effusions. The present study aimed to investigate the concentrations and potential differential significance of IL-33 in patients with TPE and MPE. IL-33 levels in pleural effusion and serum samples were detected using sandwich enzyme-linked immunosorbent assay in 23 patients with TPE and 21 patients with MPE. The concentration of IL-33 (mean ± standard deviation) in the TPE patients (22.962±0.976 ng/l) was significantly higher than that in the MPE patients (12.603±5.153 ng/l; P<0.001; z=-4.572); however, there was no significant difference in the serum level of IL-33 in the patients with TPE compared with those with MPE (P>0.05). The concentration of IL-33 in the pleural effusions was positively correlated with that in the serum samples in each group (TPE: r=0.563, P=0.05; MPE: r=0.535, P<0.05). The cut-off value of pleural IL-33 for TPE was 19.86 ng/l, which yielded a sensitivity of 0.869, a specificity of 0.905 and an area under the corresponding receiver operating characteristic curve of 0.903. The present study identified that the level of pleural IL-33 is significantly increased in TPEs and may serve as a novel biomarker to differentiate between patients with TPE and MPE.
在某些临床情况下，结核性胸腔积液（TPE）和恶性胸腔积液（MPE）难以鉴别。白细胞介素（IL）-33是一种参与炎症反应的细胞因子，可能在胸腔积液中发挥作用。本研究旨在探讨IL-33在TPE和MPE患者中的浓度及潜在的鉴别意义。采用夹心酶联免疫吸附测定法检测了23例TPE患者和21例MPE患者胸腔积液和血清样本中的IL-33水平。TPE患者中IL-33的浓度（均值±标准差）为（22.962±0.976）ng/l，显著高于MPE患者（12.603±5.153）ng/l；P<0.001；z=-4.572）；然而，TPE患者与MPE患者血清中IL-33水平无显著差异（P>0.05）。每组胸腔积液中IL-33的浓度与血清样本中的浓度呈正相关（TPE：r=0.563，P=0.05；MPE：r=0.535，P<0.05）。TPE的胸腔IL-33临界值为19.86 ng/l，灵敏度为0.869，特异度为0.905，相应的受试者工作特征曲线下面积为0.903。本研究发现，TPE患者胸腔IL-33水平显著升高，可能作为鉴别TPE和MPE患者的一种新型生物标志物。
