经典型霍奇金淋巴瘤中的免疫调节异常
Immunological deregulation in classic hodgkin lymphoma.
作者信息
Romano Alessandra, Vetro Calogero, Caocci Giovanni, Greco Marianna, Parrinello Nunziatina Laura, Di Raimondo Francesco, La Nasa Giorgio
机构信息
Division of Haematology, Azienda Ospedaliera "Policlinico-Vittorio Emanuele", University of Catania. Via Citelli 6, 95124 Catania, Italy.
Hematology Unit, Department of Medical Sciences "Mario Aresu," University of Cagliari, Italy.
出版信息
Mediterr J Hematol Infect Dis. 2014 Jun 1;6(1):e2014039. doi: 10.4084/MJHID.2014.039. eCollection 2014.
Abstract
Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications.
摘要
经典型霍奇金淋巴瘤（cHL）具有独特的组织学特征，因为只有少数肿瘤细胞被炎性辅助细胞所包围，近年来这些炎性辅助细胞已成为维持疾病进程的关键因素。此外，最近的研究表明，这些炎性细胞的异常活性（如调节性T细胞信号传导失调、髓源性抑制细胞扩增、HLA-G信号传导和自然杀伤细胞功能障碍）可能具有预后意义。本综述着重总结cHL免疫缺陷方面的最新进展及其转化意义。
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