Jia T, Zhu H Y, Wang L, Liang J H, Cao L, Xia Y, Wu J Z, Wu W, Fan L, Li J Y, Xu W
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China; Department of Hematology, the First People's Hospital of Lianyungang, Lianyungang 222002, China.
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
Zhonghua Xue Ye Xue Za Zhi. 2019 May 14;40(5):372-377. doi: 10.3760/cma.j.issn.0253-2727.2019.05.005.
To evaluate the prognostic value of lymphocyte to monocyte ratio (LMR) and PET scan performed after first two cycles of chemotherapy (PET-2) in Hodgkin's lymphoma (HL) . The clinical data of 133 patients with HL diagnosed from January 2007 to March 2016 at the First Affiliated Hospital of Nanjing Medical University, were retrospectively analyzed. The X-tile software was used to calculate the optimal cut-off value of LMR. Kaplan-Meier method and Cox regression were used for survival analysis. The median age of 133 HL patients was 33 (18-84) years, and the male to female ratio was 1.9∶1. The optimal cut-off value of LMR was 2.5, and progression free survival (PFS) (<0.001) and overall survival (OS) (<0.001) were significantly lower in the LMR<2.5 group than that of LMR≥2.5. Multivariate survival analysis showed that LMR<2.5 was an independent predictor of PFS (=0.002, =2.35, 95% 1.36-4.07) and OS (=0.002, =10.36, 95% 2.35-45.66) in HL patients. The analysis of PET-2 from 56 HL patients showed that PET-2 positive patients had significantly poorer PFS (=0.022) . After grouping LMR combined with PET-2, significant differences were found in PFS and OS between the three groups ( values were 0.009 and 0.012) . LMR<2.5 is an independent prognostic factor for patients with HL. PET-2 combined with LMR may have better prognostic value.
评估淋巴细胞与单核细胞比值（LMR）及化疗前两个周期后进行的PET扫描（PET-2）在霍奇金淋巴瘤（HL）中的预后价值。回顾性分析了2007年1月至2016年3月在南京医科大学第一附属医院确诊的133例HL患者的临床资料。使用X-tile软件计算LMR的最佳截断值。采用Kaplan-Meier法和Cox回归进行生存分析。133例HL患者的中位年龄为33（18-84）岁，男女比例为1.9∶1。LMR的最佳截断值为2.5，LMR<2.5组的无进展生存期（PFS）（<0.001）和总生存期（OS）（<0.001）显著低于LMR≥2.5组。多因素生存分析显示，LMR<2.5是HL患者PFS（=0.002，=2.35，95% 1.36-4.07）和OS（=0.002，=10.36，95% 2.35-45.66）的独立预测因素。对56例HL患者的PET-2分析显示，PET-2阳性患者的PFS显著更差（=0.022）。将LMR与PET-2分组后，三组之间的PFS和OS存在显著差异（值分别为0.009和0.012）。LMR<2.5是HL患者的独立预后因素。PET-2与LMR联合可能具有更好的预后价值。
