Dhillon Manu, Tomar Divya, Sharma Manu, Goel Samta, Srivastava Siddharth
Senior Lecturer, Department of Oral Medicine and Radiology, ITS Centre for Dental Studies and Research , Ghaziabad, India .
Senior Lecturer, Department of Pedodontics and Preventive Dentistry, SBB Dental College , Ghaziabad, India .
J Clin Diagn Res. 2014 Apr;8(4):QD04-6. doi: 10.7860/JCDR/2014/8041.4248. Epub 2014 Apr 15.
Pleomorphic adenoma originally called the mixed tumour is a neoplasm commonly involving major salivary glands. The spectrum of malignancy in pleomorphic adenoma comprises three distinct entities - Carcinoma ex pleomorphic adenoma, carcinosarcoma and benign metastasising pleomorphic adenoma. Carcinoma ex pleomorphic adenoma consists of pleomorphic adenoma with a malignant epithelial component. Occasionally, carcinomas ex pleomorphic adenoma develops metastasis. Here we are reporting here a case of benign pleomorphic adenoma arising in parotid gland which turned into malignancy after four years. The patient developed facial nerve paralysis suggesting malignant transformation. Along the course of the disease, the patient developed regional metastasis to lymph nodes and neck and distant metastasis to liver. This case report emphasises the role of advanced imaging modalities in the early diagnosis of the condition and evaluation of metastasis. The patients with this condition should be treated early for favorable outcome and investigated for distant metastasis.
多形性腺瘤最初被称为混合瘤,是一种常见于大唾液腺的肿瘤。多形性腺瘤的恶性谱系包括三个不同的实体——多形性腺瘤恶变、癌肉瘤和良性转移性多形性腺瘤。多形性腺瘤恶变由多形性腺瘤和恶性上皮成分组成。偶尔,多形性腺瘤恶变会发生转移。在此,我们报告一例发生于腮腺的良性多形性腺瘤,四年后恶变。患者出现面神经麻痹提示恶变。在疾病过程中,患者出现区域淋巴结转移至颈部,远处转移至肝脏。本病例报告强调了先进成像方式在该疾病早期诊断和转移评估中的作用。患有这种疾病的患者应尽早治疗以获得良好预后,并进行远处转移检查。