Qureshi Asim, Barakzai Abrar, Sahar Najam Ul, Gulzar Rubina, Ahmad Zubair, Hassan Sheema H
Section of Histopathology, Aga Khan University, Karachi, Pakistan.
Indian J Pathol Microbiol. 2009 Apr-Jun;52(2):150-4. doi: 10.4103/0377-4929.48904.
Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor.
涎腺混合瘤中发生的恶性肿瘤是一种独特的实体，可散发性出现或与多形性腺瘤背景相关。多形性腺瘤背景下发生的癌已有充分记载。然而，有报道称腮腺发生侵袭性原发性癌肉瘤的情况罕见。涉及多种细胞谱系，如上皮腺细胞和间质梭形细胞。我们报告了23例涎腺肿瘤，包括18例多形性腺瘤恶变、4例腮腺癌肉瘤和1例良性转移性多形性腺瘤。各种恶性肿瘤的发生表明这种现象并不十分罕见，在报告混合瘤时应予以关注。
