Jilanchi Sima, Nematbakhsh Mehdi, Bahadorani Mehrnoosh, Talebi Ardeshir, Eshraghi-Jazi Fatemeh, Mansouri Azam, Ashrafi Farzaneh
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Deparment of Biology, Falavarjan Branch, Islamic Azad University, Isfahan 84515, Iran.
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
ISRN Nephrol. 2013 Jun 23;2013:280395. doi: 10.5402/2013/280395. eCollection 2013.
Background. The role of gender for nephroprotectant agent such as vitamin E in cisplatin- (CP-) induced nephrotoxicity has not been documented yet. Methods. One group from each gender of Wistar rats received a single dose of CP (7 mg/kg; i.p) and was treated with vitamin E (1 g/kg/day) for 7 days, and they were compared with similar gender in the control group. Results. The serum levels of blood urea nitrogen (BUN) and creatinine (Cr) in male animals treated with CP was not different from the control group, but it was significantly different in the female rats (P < 0.05). The CP-induced damage intensity in male kidney tissue was not significantly different between the CP-treated and control groups, but this was not the case in female, indicating that the tissue damage in female is significantly different from the control group (P < 0.05). No significant difference in serum levels of magnesium (Mg), nitrite, malondialdehyde (MDA), and lactate dehydrogenase (LDH) was seen between the genders. Kidney weight and body weight changes were statistically significant in both genders (P < 0.05). Significant difference was observed in uterus weight between the two groups of female (P < 0.05). Conclusion. Vitamin E may prevent CP-induced nephrotoxicity in male, but possibly it has not such nephroprotectant effect in female.
背景。性别对于肾保护剂如维生素E在顺铂（CP）诱导的肾毒性中的作用尚未有文献记载。方法。将每组不同性别的Wistar大鼠给予单剂量的CP（7毫克/千克；腹腔注射），并用维生素E（1克/千克/天）治疗7天，然后将它们与对照组中相同性别的大鼠进行比较。结果。用CP治疗的雄性动物的血清尿素氮（BUN）和肌酐（Cr）水平与对照组无差异，但在雌性大鼠中则有显著差异（P<0.05）。CP诱导的雄性肾组织损伤强度在CP治疗组和对照组之间无显著差异，但雌性则不然，表明雌性的组织损伤与对照组有显著差异（P<0.05）。性别之间在血清镁（Mg）、亚硝酸盐、丙二醛（MDA）和乳酸脱氢酶（LDH）水平上未见显著差异。肾重量和体重变化在两性中均有统计学意义（P<0.05）。两组雌性之间的子宫重量有显著差异（P<0.05）。结论。维生素E可能预防雄性大鼠CP诱导的肾毒性，但可能对雌性没有这种肾保护作用。
