Tomas Cara, Newton Julia, Watson Stuart
Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Newcastle University, Newcastle upon Tyne NE1 7RU, UK ; Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
ISRN Neurosci. 2013 Sep 30;2013:784520. doi: 10.1155/2013/784520. eCollection 2013.
Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been found in a high proportion of chronic fatigue syndrome (CFS) patients and includes enhanced corticosteroid-induced negative feedback, basal hypocortisolism, attenuated diurnal variation, and a reduced responsivity to challenge. A putative causal role for genetic profile, childhood trauma, and oxidative stress has been considered. In addition, the impact of gender is demonstrated by the increased frequency of HPA axis dysregulation in females. Despite the temporal relationship, it is not yet established whether the endocrine dysregulation is causal, consequent, or an epiphenomenon of the disorder. Nonetheless, given the interindividual variation in the effectiveness of existing biological and psychological treatments, the need for novel treatment strategies such as those which target the HPA axis is clear.
下丘脑-垂体-肾上腺（HPA）轴功能障碍在很大比例的慢性疲劳综合征（CFS）患者中被发现，包括皮质类固醇诱导的负反馈增强、基础皮质醇水平低下、昼夜变化减弱以及对刺激的反应性降低。基因谱、童年创伤和氧化应激被认为可能具有因果作用。此外，女性HPA轴失调频率增加表明了性别因素的影响。尽管存在时间上的关联，但内分泌失调是该疾病的病因、后果还是一种附带现象尚未确定。然而，考虑到现有生物和心理治疗效果的个体差异，显然需要针对HPA轴等新的治疗策略。
