Kamdi S P, Palkar P J
Department of Medical Services and Clinical Research, Akumentis Healthcare Ltd , Kasarvadavali, Near Hyper City, Maharashtra , India.
J Obstet Gynaecol. 2015 Jan;35(1):4-8. doi: 10.3109/01443615.2014.930098. Epub 2014 Jun 24.
The aim of the present investigation was to compare the efficacy and safety of oral ferrous asparto glycinate and ferrous ascorbate in pregnant women with iron deficiency anaemia (IDA). We performed a double blind, prospective, randomised, multicentre, parallel group comparative clinical study at three different centres in India. A total of 73 pregnant women at 12-26 weeks' gestation were divided into two arms. While one group received ferrous ascorbate, another group was treated with ferrous asparto glycinate for a period of 28 days. The mean rise in haemoglobin and ferritin levels on day 14 and 28 was evaluated. At both time points, significantly higher levels of haemoglobin and ferritin were noticed with ferrous asparto glycinate treatment as compared with ferrous ascorbate. Our results showed that ferrous asparto glycinate is an effective iron-amino acid chelate in the management of IDA in pregnant women as compared with ferrous ascorbate. Nevertheless, additional large scale prospective, randomised trials are warranted to confirm the findings of the present efficacy trial, and also to find out the anaemia eradication rate.
本研究的目的是比较甘氨酸天冬氨酸亚铁和抗坏血酸亚铁对缺铁性贫血（IDA）孕妇的疗效和安全性。我们在印度的三个不同中心进行了一项双盲、前瞻性、随机、多中心、平行组比较临床研究。共有73名妊娠12 - 26周的孕妇被分为两组。一组接受抗坏血酸亚铁治疗，另一组接受甘氨酸天冬氨酸亚铁治疗，为期28天。评估了第14天和第28天血红蛋白和铁蛋白水平的平均升高情况。在两个时间点，与抗坏血酸亚铁相比，甘氨酸天冬氨酸亚铁治疗组的血红蛋白和铁蛋白水平显著更高。我们的结果表明，与抗坏血酸亚铁相比，甘氨酸天冬氨酸亚铁是治疗孕妇缺铁性贫血的一种有效铁氨基酸螯合物。然而，仍需要进行额外的大规模前瞻性随机试验来证实本疗效试验的结果，并找出贫血根除率。
