Huong Vu Thi Lan, Ha Ngo, Huy Nguyen Tien, Horby Peter, Nghia Ho Dang Trung, Thiem Vu Dinh, Zhu Xiaotong, Hoa Ngo Thi, Hien Tran Tinh, Zamora Javier, Schultsz Constance, Wertheim Heiman Frank Louis, Hirayama Kenji
Emerg Infect Dis. 2014 Jul;20(7):1105-14. doi: 10.3201/eid2007.131594.
Streptococcus suis, a bacterium that affects pigs, is a neglected pathogen that causes systemic disease in humans. We conducted a systematic review and meta-analysis to summarize global estimates of the epidemiology, clinical characteristics, and outcomes of this zoonosis. We searched main literature databases for all studies through December 2012 using the search term "streptococcus suis." The prevalence of S. suis infection is highest in Asia; the primary risk factors are occupational exposure and eating of contaminated food. The pooled proportions of case-patients with pig-related occupations and history of eating high-risk food were 38.1% and 37.3%, respectively. The main clinical syndrome was meningitis (pooled rate 68.0%), followed by sepsis, arthritis, endocarditis, and endophthalmitis. The pooled case-fatality rate was 12.8%. Sequelae included hearing loss (39.1%) and vestibular dysfunction (22.7%). Our analysis identified gaps in the literature, particularly in assessing risk factors and sequelae of this infection.
猪链球菌是一种感染猪的细菌，是一种被忽视的病原体，可导致人类全身性疾病。我们进行了一项系统评价和荟萃分析，以总结对这种人畜共患病的流行病学、临床特征和结局的全球估计。我们使用搜索词“猪链球菌”在主要文献数据库中检索截至2012年12月的所有研究。猪链球菌感染的患病率在亚洲最高；主要危险因素是职业暴露和食用受污染的食物。从事与猪相关职业和有食用高风险食物史的病例患者的合并比例分别为38.1%和37.3%。主要临床综合征为脑膜炎（合并率68.0%），其次是败血症、关节炎、心内膜炎和眼内炎。合并病死率为12.8%。后遗症包括听力丧失（39.1%）和前庭功能障碍（22.7%）。我们的分析发现了文献中的空白，特别是在评估这种感染的危险因素和后遗症方面。
