Yang Jinghui, Liu Jianwei, Liu Jing, Li Wenyuan, Li Xiaoying, He Yao, Ye Ling
Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
PLoS One. 2014 Jun 24;9(6):e100548. doi: 10.1371/journal.pone.0100548. eCollection 2014.
The metabolic syndrome (MetS) has been known as partly heritable, while the number of genetic studies on MetS and metabolic-related traits among Chinese elderly was limited.
A cross-sectional analysis was performed among 2 014 aged participants from September 2009 to June 2010 in Beijing, China. An additional longitudinal study was carried out among the same study population from 2001 to 2010. Biochemical profile and anthropometric parameters of all the participants were measured. The associations of 23 SNPs located within 17 candidate genes (MTHFR, PPARγ, LPL, INSIG, TCF7L2, FTO, KCNJ11, JAZF1, CDKN2A/B, ADIPOQ, WFS1, CDKAL1, IGF2BP2, KCNQ1, MTNR1B, IRS1, ACE) with overweight and obesity, diabetes, metabolic phenotypes, and MetS were examined in both studies.
In this Chinese elderly population, prevalence of overweight, central obesity, diabetes, dyslipidemia, hypertension, and MetS were 48.3%, 71.0%, 32.4%, 75.7%, 68.3% and 54.5%, respectively. In the cross-sectional analyses, no SNP was found to be associated with MetS. Genotype TT of SNP rs4402960 within the gene IGF2BP2 was associated with overweight (odds ratio (OR) = 0.479, 95% confidence interval (CI): 0.316-0.724, p = 0.001) and genotype CA of SNP rs1801131 within the gene MTHFR was associated with hypertension (OR = 1.560, 95% CI: 1.194-2.240, p = 0.001). However, these associations were not observed in the longitudinal analyses.
The associations of SNP rs4402960 with overweight as well as the association of SNP rs1801131 with hypertension were found to be statistically significant. No SNP was identified to be associated with MetS in our study with statistical significance.
代谢综合征（MetS）具有部分遗传性，然而针对中国老年人的代谢综合征及代谢相关性状的基因研究数量有限。
2009年9月至2010年6月期间，对来自中国北京的2014名老年参与者进行了横断面分析。2001年至2010年期间，对同一研究人群开展了一项额外的纵向研究。测量了所有参与者的生化指标和人体测量参数。在两项研究中，均检测了位于17个候选基因（MTHFR、PPARγ、LPL、INSIG、TCF7L2、FTO、KCNJ11、JAZF1、CDKN2A/B、ADIPOQ、WFS1、CDKAL1、IGF2BP2、KCNQ1、MTNR1B、IRS1、ACE）内的23个单核苷酸多态性（SNP）与超重、肥胖、糖尿病、代谢表型及代谢综合征之间的关联。
在中国老年人群中，超重、中心性肥胖、糖尿病、血脂异常、高血压及代谢综合征的患病率分别为48.3%、71.0%、32.4%、75.7%、68.3%和54.5%。在横断面分析中，未发现有SNP与代谢综合征相关。IGF2BP2基因内的SNP rs4402960的基因型TT与超重相关（优势比（OR）=0.479，95%置信区间（CI）：0.316-0.724，p=0.001），MTHFR基因内的SNP rs1801131的基因型CA与高血压相关（OR=1.560，95%CI：1.194-2.240，p=0.001）。然而，在纵向分析中未观察到这些关联。
发现SNP rs4402960与超重的关联以及SNP rs1801131与高血压的关联具有统计学意义。在我们的研究中，未发现有SNP与代谢综合征具有统计学意义的关联。
