Priority Research Centre in Physical Activity and Nutrition and School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
School of Psychology, Faculty of Science and IT, University of Newcastle, Callaghan, NSW 2308, Australia.
Nutrients. 2014 Jun 23;6(6):2419-35. doi: 10.3390/nu6062419.
Rates of iron deficiency are high amongst healthy young women. Cognitive impairment occurs secondary to iron deficiency in infants and children, but evaluation of the impact on cognition among young women is inconsistent. The aim was to determine the suitability of the IntegNeuro test battery for assessing cognitive function in iron-deficient and iron-sufficient young women. A pilot double-blinded, placebo-controlled intervention trial was conducted in iron-deficient (serum ferritin ≤ 20 μg/L and haemoglobin > 120 g/L) and iron-sufficient young women (18-35 years). Cognitive function and haematological markers of iron status were measured at baseline and follow-up. Iron-deficient participants (n = 24) were randomised to receive placebo, 60 mg or 80 mg elemental iron daily supplements for 16 weeks. A control group of iron-sufficient participants (n = 8) was allocated to placebo. Change scores for Impulsivity and Attention were significantly greater in plasma ferritin improvers than in non-improvers (p = 0.004, p = 0.026). IntegNeuro was easy to administer and acceptable to young women. Based on the differences in Memory and Attention scores between iron-deficient participants on iron treatment and those on placebo, it was decided that between 26 and 84 participants would be required in each iron treatment group for an adequately powered extension of this pilot RCT.
健康年轻女性缺铁的发生率很高。婴儿和儿童缺铁会导致认知障碍，但评估缺铁对年轻女性认知的影响结果并不一致。本研究旨在确定 IntegNeuro 测试组合在评估缺铁和铁充足的年轻女性认知功能方面的适用性。在缺铁（血清铁蛋白≤20μg/L 和血红蛋白>120g/L）和铁充足（18-35 岁）的年轻女性中进行了一项试点双盲、安慰剂对照干预试验。在基线和随访时测量认知功能和铁状态的血液学标志物。将 24 名缺铁参与者随机分为安慰剂组、60mg 或 80mg 元素铁每日补充剂组，治疗 16 周。将 8 名铁充足的对照组参与者分配至安慰剂组。与非改善者相比，血清铁蛋白改善者的冲动性和注意力的变化评分显著更高（p=0.004，p=0.026）。IntegNeuro 易于管理，并且被年轻女性所接受。基于铁治疗组和安慰剂组缺铁参与者的记忆和注意力评分之间的差异，决定在每个铁治疗组中需要 26 至 84 名参与者，以便对这项试点 RCT 进行充分有力的扩展。
