细胞外钙和钠对豚鼠及兔主动脉摄取镉的影响。

Effects of extracellular calcium and sodium on cadmium uptake in guinea-pig and rabbit aorta.

Ueda F, Nagata M, Nagata T, Shimazaki Y

Department of Veterinary Public Health, Nippon Veterinary and Zootechnical College, Tokyo, Japan.

Gen Pharmacol. 1989;20(1):85-7. doi: 10.1016/0306-3623(89)90066-9.

Abstract

Effects of Na+ and Ca2+ on Cd2+ uptake in the guinea-pig and rabbit aorta were investigated. 2. The Cd2+ fraction can be divided with EDTA and Zn2+. The EDTA fraction may be intracellular fraction and the Zn2+ fraction may be loosely bound to surface membrane. 3. In Na+ deficient solution the Zn2+ fraction was markedly increased and the EDTA fraction also increased while the external Ca2+ concentrations scarcely affect the Cd2+ contents in both fractions. 4. Cd2+ did not affect the cellular Na+ and K+ contents. 5. These results suggest that Na+ strongly relates with these fractions but Na+ pump does not contribute to these phenomena.

摘要

研究了Na⁺和Ca²⁺对豚鼠和家兔主动脉摄取Cd²⁺的影响。2. Cd²⁺部分可用EDTA和Zn²⁺分离。EDTA部分可能是细胞内部分，而Zn²⁺部分可能与表面膜松散结合。3. 在缺Na⁺溶液中，Zn²⁺部分显著增加，EDTA部分也增加，而外部Ca²⁺浓度几乎不影响这两个部分中的Cd²⁺含量。4. Cd²⁺不影响细胞内Na⁺和K⁺含量。5. 这些结果表明，Na⁺与这些部分密切相关，但Na⁺泵对这些现象没有作用。