阿霉素对小鼠组织中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性的影响。
Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice.
作者信息
Sazuka Y, Tanizawa H, Takino Y
机构信息
School of Pharmaceutical Sciences, University of Shizuoka.
出版信息
Jpn J Cancer Res. 1989 Jan;80(1):89-94. doi: 10.1111/j.1349-7006.1989.tb02250.x.
Abstract
The increment of lipid peroxide in the hearts of mice treated with adriamycin (ADR) was examined in relation to the decrease in the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHpx) and catalase. The natural activities of these enzymes in mouse heart are lower than those in the liver. The biggest decrease in enzyme activity observed in the heart after ADR administration was that of GSHpx. Therefore, the increment of lipid peroxide was attributable to the decrease in the activities of these enzymes, especially GSHpx. Subsequently, the effects of antioxidants on the decreases in activities of SOD, GSHpx and catalase in the hearts of mice treated with ADR were examined. However, the decrease in the activities of the enzymes were not accompanied with any increment of lipid peroxide. This result suggests that active oxygen radicals produced by ADR through the agent's redox cycling have no effect on the activities of these enzymes. Therefore, it appears that the decrease in the activities of these enzymes induced by ADR in the mouse results from inhibition of enzyme protein biosynthesis.
摘要
研究了阿霉素（ADR）处理的小鼠心脏中脂质过氧化物的增加与超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSHpx）和过氧化氢酶活性降低之间的关系。这些酶在小鼠心脏中的天然活性低于肝脏中的活性。ADR给药后在心脏中观察到的酶活性最大降幅是GSHpx的降幅。因此，脂质过氧化物的增加归因于这些酶活性的降低，尤其是GSHpx。随后，研究了抗氧化剂对ADR处理的小鼠心脏中SOD、GSHpx和过氧化氢酶活性降低的影响。然而，酶活性的降低并未伴随着脂质过氧化物的任何增加。该结果表明，ADR通过其氧化还原循环产生的活性氧自由基对这些酶的活性没有影响。因此，似乎ADR诱导的小鼠中这些酶活性的降低是由于酶蛋白生物合成受到抑制。
相似文献
1
Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice.阿霉素对小鼠组织中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性的影响。
Jpn J Cancer Res. 1989 Jan;80(1):89-94. doi: 10.1111/j.1349-7006.1989.tb02250.x.
2
Induction of antioxidants by adriamycin in mouse heart.阿霉素对小鼠心脏抗氧化剂的诱导作用。
Biochem Pharmacol. 1998 Jul 1;56(1):87-93. doi: 10.1016/s0006-2952(98)00099-9.
3
Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation.顺铂对防止脂质过氧化的酶活性的影响。
Biochem Pharmacol. 1992 Apr 15;43(8):1872-5. doi: 10.1016/0006-2952(92)90725-x.
4
Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication.四氯化碳中毒后大鼠不同组织中过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性
J Hepatobiliary Pancreat Surg. 2003;10(4):309-15. doi: 10.1007/s00534-002-0824-5.
5
Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats.普罗布考对阿霉素诱导的大鼠心肌病中抗氧化酶变化的影响。
Cardiovasc Res. 2000 Jun;46(3):523-30. doi: 10.1016/s0008-6363(00)00039-0.
6
Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol.阿霉素诱导的心肌抗氧化酶早期变化及其被普罗布考的调节作用。
Circulation. 2000 Oct 24;102(17):2105-10. doi: 10.1161/01.cir.102.17.2105.
7
Early changes in myocardial antioxidant enzymes in rats treated with adriamycin.阿霉素处理大鼠心肌抗氧化酶的早期变化。
Mol Cell Biochem. 2002 Mar;232(1-2):19-26. doi: 10.1023/a:1014862912783.
8
Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.食物限制会改变雄性费希尔344大鼠各种组织中抗氧化酶的活性。
J Nutr. 1995 Feb;125(2):195-201. doi: 10.1093/jn/125.2.195.
9
Effect of seasonal variation on lipid peroxide level and glutathione peroxidase activity in the mouse before and after adriamycin administration.阿霉素给药前后季节性变化对小鼠脂质过氧化物水平和谷胱甘肽过氧化物酶活性的影响。
Toxicol Lett. 1992 Jun;61(1):49-56. doi: 10.1016/0378-4274(92)90062-o.
10
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin.小鼠心脏针对活性氧代谢产物的酶防御机制：阿霉素引起的改变
J Clin Invest. 1980 Jan;65(1):128-35. doi: 10.1172/JCI109642.
引用本文的文献
1
Argan Fruit Polyphenols Regulate Lipid Homeostasis, Prevent Liver Fat Accumulation, and Improve Antioxidant Defense in High-Calorie Diet Fed Mice: In Vivo Study and In Silico Prediction of Possible Underlying Mechanisms.阿甘油果多酚调节高脂饮食喂养小鼠的脂质稳态、预防肝脏脂肪堆积并改善抗氧化防御：体内研究及潜在机制的计算机模拟预测
Metabolites. 2025 Mar 28;15(4):234. doi: 10.3390/metabo15040234.
2
Antidiarrheal and antioxidant activities of (L.) leave extract.（某植物拉丁名）叶提取物的止泻和抗氧化活性
Heliyon. 2023 Oct 21;9(11):e21139. doi: 10.1016/j.heliyon.2023.e21139. eCollection 2023 Nov.
3
Acute and Delayed Doxorubicin-Induced Myocardiotoxicity Associated with Elevation of Cardiac Biomarkers, Depletion of Cellular Antioxidant Enzymes, and Several Histopathological and Ultrastructural Changes.急性和迟发性阿霉素诱导的心肌毒性与心脏生物标志物升高、细胞抗氧化酶耗竭以及多种组织病理学和超微结构变化相关。
Life (Basel). 2021 Aug 27;11(9):880. doi: 10.3390/life11090880.
4
The Therapeutic Role of Slit2 in Anti-fibrosis, Anti-inflammation and Anti-oxidative Stress in Rats with Coronary Heart Disease.Slit2 在冠心病大鼠抗纤维化、抗炎及抗氧化应激中的治疗作用。
Cardiovasc Toxicol. 2021 Dec;21(12):973-983. doi: 10.1007/s12012-021-09688-5. Epub 2021 Aug 19.
5
The effect of heavy metal contamination on humans and animals in the vicinity of a zinc smelting facility.锌冶炼厂附近重金属污染对人类和动物的影响。
PLoS One. 2019 Oct 28;14(10):e0207423. doi: 10.1371/journal.pone.0207423. eCollection 2019.
6
Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions.芦丁和奥利司他通过抗氧化和凋亡作用产生抗肿瘤作用。
Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb;392(2):165-175. doi: 10.1007/s00210-018-1579-0. Epub 2018 Nov 21.
7
Is the combinational administration of doxorubicin and glutathione a reasonable proposal?多柔比星与谷胱甘肽联合给药是否合理？
Acta Pharmacol Sin. 2019 May;40(5):699-709. doi: 10.1038/s41401-018-0158-8. Epub 2018 Sep 14.
8
A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats.亚麻籽油和虾青素联合使用可改善高脂饮食喂养大鼠的肝脏脂质积累并减轻氧化应激。
Nutrients. 2017 Mar 13;9(3):271. doi: 10.3390/nu9030271.
9
Single frequency intake of α-linolenic acid rich phytosterol esters attenuates atherosclerosis risk factors in hamsters fed a high fat diet.富含α-亚麻酸的植物甾醇酯单频摄入可减轻高脂饮食喂养仓鼠的动脉粥样硬化风险因素。
Lipids Health Dis. 2016 Feb 3;15:23. doi: 10.1186/s12944-016-0185-8.
10
Curcumin Stimulates the Antioxidant Mechanisms in Mouse Skin Exposed to Fractionated γ-Irradiation.姜黄素刺激经分次γ射线照射的小鼠皮肤中的抗氧化机制。
Antioxidants (Basel). 2015 Jan 13;4(1):25-41. doi: 10.3390/antiox4010025.
本文引用的文献
1
Does catalase play a role in adriamycin induced cardiotoxicity?过氧化氢酶在阿霉素诱导的心脏毒性中起作用吗？
Pharmacol Res Commun. 1980 May;12(5):441-6. doi: 10.1016/s0031-6989(80)80114-7.
2
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin.小鼠心脏针对活性氧代谢产物的酶防御机制：阿霉素引起的改变
J Clin Invest. 1980 Jan;65(1):128-35. doi: 10.1172/JCI109642.
3
Micro-determination of lipoperoxide in the mouse myocardium by thiobarbituric acid fluorophotometry.
Chem Pharm Bull (Tokyo). 1981 Oct;29(10):2910-4. doi: 10.1248/cpb.29.2910.
4
The influence of selenium intake on chronic adriamycin toxicity and lipid peroxidation in rats.硒摄入量对大鼠慢性阿霉素毒性及脂质过氧化的影响。
Toxicol Lett. 1983 Mar;15(4):301-7. doi: 10.1016/0378-4274(83)90148-0.
5
Distribution of selenium and glutathione peroxidase in the rat.大鼠体内硒和谷胱甘肽过氧化物酶的分布
J Nutr. 1983 Feb;113(2):456-61. doi: 10.1093/jn/113.2.456.
6
Change of lipid peroxide levels in mouse organs after adriamycin administration.阿霉素给药后小鼠器官中脂质过氧化物水平的变化。
Chem Pharm Bull (Tokyo). 1983 May;31(5):1714-8. doi: 10.1248/cpb.31.1714.
7
Species, strain, sex and weekly age differences of lipid peroxide levels in animal tissues before and after adriamycin administration.阿霉素给药前后动物组织中脂质过氧化物水平的物种、品系、性别和周龄差异。
Chem Pharm Bull (Tokyo). 1984 Oct;32(10):4110-6. doi: 10.1248/cpb.32.4110.
8
Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex.阿霉素-铁（III）复合物的自身还原所刺激的脂质过氧化作用及可能的羟基自由基形成。
Biochem Pharmacol. 1984 Jun 1;33(11):1725-8. doi: 10.1016/0006-2952(84)90340-x.
9
Comparative biochemical studies of adriamycin and daunomycin in leukemic cells.
Cancer Res. 1972 Mar;32(3):511-5.
10
Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat.日粮硒对大鼠红细胞和肝脏谷胱甘肽过氧化物酶的影响。
J Nutr. 1974 May;104(5):580-7. doi: 10.1093/jn/104.5.580.
Zotero 插件