Sadzuka Y, Takino Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Toxicol Lett. 1992 Jun;61(1):49-56. doi: 10.1016/0378-4274(92)90062-o.
We examined the effect of seasonal variation on lipid peroxide levels and glutathione peroxidase (GSHpx) activity in tissues of normal and adriamycin (ADR)-treated mice. In the heart, normal lipid peroxide levels and GSHpx activity in November, December and January were lower than in other months. For the same period, lipid peroxide levels were higher and GSHpx activity lower in mice hearts after ADR administration. The results of GSHpx activity support those of lipid peroxide levels. We conclude that ADR-induced cardiotoxicity, related to the rise in level of lipid peroxide in mice hearts, is more likely to occur in winter than in other seasons.
我们研究了季节变化对正常小鼠和阿霉素（ADR）处理小鼠组织中脂质过氧化物水平和谷胱甘肽过氧化物酶（GSHpx）活性的影响。在心脏中，11月、12月和1月正常小鼠的脂质过氧化物水平和GSHpx活性低于其他月份。在同一时期，ADR给药后小鼠心脏中的脂质过氧化物水平较高而GSHpx活性较低。GSHpx活性的结果与脂质过氧化物水平的结果相符。我们得出结论，ADR诱导的心脏毒性与小鼠心脏中脂质过氧化物水平升高有关，在冬季比在其他季节更易发生。
