Balta Ilknur, Ekiz Ozlem, Ozuguz Pınar, Ustun Ihsan, Karaca Semsettin, Dogruk Kacar Seval, Eksioglu Meral
Department of Dermatology, Kecioren Training and Research Hospital, Ministry of Health, Ankara, Turkey.
Department of Dermatology, Tayfur Ata Sokmen School of Medicine, Mustafa Kemal University, Hatay, Turkey.
Int J Dermatol. 2015 Jun;54(6):662-6. doi: 10.1111/ijd.12426. Epub 2014 Jun 25.
Post-adolescent acne has been defined as acne in a patient aged >25 years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne.
This study was conducted in order to investigate the relationship between post-adolescent acne and insulin resistance.
The study population comprised 35 patients with post-adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated for each individual.
No significant differences were observed between patients with post-adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL-C levels, and HOMA-IR index. There were also no correlations between these parameters and the severity of acne.
This study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.
青春期后痤疮被定义为年龄大于25岁患者的痤疮。寻常痤疮最初在青春期开始时因激素变化而出现。在青春期，胰岛素敏感性会出现短暂下降。我们推测青春期后痤疮患者在青春期后可能仍存在胰岛素抵抗。
本研究旨在调查青春期后痤疮与胰岛素抵抗之间的关系。
研究人群包括35例青春期后痤疮患者和35名健康对照者。测量的参数包括空腹血糖、胰岛素、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）、总胆固醇（TC）、甘油三酯、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。为每个个体计算胰岛素抵抗的稳态模型评估（HOMA-IR）指数。
青春期后痤疮患者与对照者在空腹血糖、空腹胰岛素、AST、ALT、甘油三酯和HDL-C水平以及HOMA-IR指数方面未观察到显著差异。这些参数与痤疮严重程度之间也无相关性。
本研究表明胰岛素抵抗可能在青春期后痤疮的发病机制中不发挥主要作用。在青春期后痤疮的发生发展中应考虑激素变化、遗传易感性、压力、化妆品使用、药物及环境因素。
