Wu Liang, Zhu Sheng-Cai, He Yang, Zhu Yun-Xia, Ou-Yang Xiao-Liang, Zhang Deng, Li Chun-Ming
Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Front Med (Lausanne). 2025 Jan 15;11:1538373. doi: 10.3389/fmed.2024.1538373. eCollection 2024.
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) compared to healthy controls. Hence, they concluded that an unhealthy lipid profile is an independent risk factor for AV. Recent research in metabolomics and lipidomics has been propelled by rapid advancements in technologies including computational methods and mass spectrometry. Using metabolomics and lipidomics approach, a broad range of structurally diverse lipid species were detected and important lipid biomarkers were identified that are vital to the pathogenesis of AV. In this review, we will describe the recent progress in dyslipidemia of AV using metabolomics and lipidomics advances. We will begin with a literature overview of dyslipidemia of AV, followed by a short introduction of metabolomics and lipidomics. Finally, we will focus on applying metabolomics and lipidomics in dyslipidemia of AV.
寻常痤疮（AV）是一种常见的累及毛囊皮脂腺单位的炎症性疾病。许多研究报告称，与健康对照相比，AV患者的总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-c）水平更高。因此，他们得出结论，不健康的脂质谱是AV的一个独立危险因素。代谢组学和脂质组学的最新研究受到了包括计算方法和质谱在内的技术快速发展的推动。使用代谢组学和脂质组学方法，检测到了广泛的结构多样的脂质种类，并确定了对AV发病机制至关重要的重要脂质生物标志物。在这篇综述中，我们将利用代谢组学和脂质组学的进展描述AV血脂异常的最新进展。我们将首先对AV血脂异常进行文献综述，然后简要介绍代谢组学和脂质组学。最后，我们将重点关注代谢组学和脂质组学在AV血脂异常中的应用。
