九里香醌A和6-甲氧基-3,7-二甲基-2,3-二氢-1H-咔唑-1,4(9H)-二酮的抗菌活性

Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione.

作者信息

Chakraborty Biswanath, Chakraborty Suchandra, Saha Chandan

机构信息

Department of Biochemistry & Medical Biotechnology, School of Tropical Medicine, Kolkata 700073, India.

Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, India.

出版信息

Int J Microbiol. 2014;2014:540208. doi: 10.1155/2014/540208. Epub 2014 May 20.

DOI:10.1155/2014/540208

PMID:24963299

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4055288/

Abstract

The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas sp.) bacteria. Compound 10 showed antibacterial activities against both of Escherichia coli and Staphylococcus aureus whereas compound 11 indicated the activity against Staphylococcus aureus only. Both compounds 10 and 11 exhibited minimum inhibitory concentration (MIC) of 50 μ g mL(-1) against Staphylococcus aureus.

摘要

在咔唑霉素G合成过程中得到的、具有独特醌部分的天然咔唑并醌生物碱默里醌A（10）和合成咔唑并醌6-甲氧基-3,7-二甲基-2,3-二氢-1H-咔唑-1,4(9H)-二酮（11）的抗菌活性，针对革兰氏阳性菌（枯草芽孢杆菌和金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌和假单胞菌属）进行了研究。化合物10对大肠杆菌和金黄色葡萄球菌均显示出抗菌活性，而化合物11仅对金黄色葡萄球菌有活性。化合物10和11对金黄色葡萄球菌的最低抑菌浓度（MIC）均为50 μg mL⁻¹。