Zhang Zhiyuan, Lin Chia-Ching John
Department of Neurosurgery, Nanjing Jinling Hospital, School of Medicine, Nanjing University, Jiangsu Province, China; Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Eur J Neurosci. 2014 Sep;40(6):2859-66. doi: 10.1111/ejn.12655. Epub 2014 Jun 25.
Glioblastoma (GBM) is by far the most common and most malignant primary adult brain tumor (World Health Organization grade IV), containing a fraction of stem-like cells that are highly tumorigenic and multipotent. Recent research has revealed that GBM stem-like cells play important roles in GBM pathogenesis. GBM is thought to arise from genetic anomalies in glial development. Over the past decade, a wide range of studies have shown that several signaling pathways involved in neural development, including basic helix-loop-helix, Wnt-β-catenin, bone morphogenetic proteins-Smads, epidermal growth factor-epidermal growth factor receptor, and Notch, play important roles in GBM pathogenesis. In this review, we highlight the significance of these pathways in the context of developing treatments for GBM. Extrapolating knowledge and concepts from neural development will have significant implications for designing better strategies with which to treat GBM.
胶质母细胞瘤（GBM）是目前最常见且最具侵袭性的原发性成人大脑肿瘤（世界卫生组织IV级），其中含有一部分具有高度致瘤性和多能性的干细胞样细胞。最近的研究表明，GBM干细胞样细胞在GBM发病机制中起着重要作用。GBM被认为起源于神经胶质发育过程中的基因异常。在过去十年中，大量研究表明，包括碱性螺旋-环-螺旋、Wnt-β-连环蛋白、骨形态发生蛋白-Smads、表皮生长因子-表皮生长因子受体和Notch在内的几种参与神经发育的信号通路，在GBM发病机制中发挥着重要作用。在本综述中，我们强调这些通路在GBM治疗发展背景下的重要性。从神经发育中推断知识和概念将对设计更好的GBM治疗策略产生重大影响。
