Unidad de Neurobiología Molecular, Área de Biología Celular y del Desarrollo, Instituto de Salud Carlos III, Ctra. Pozuelo-Majadahonda, km 2, 28220 Madrid, Spain.
Mol Neurobiol. 2011 Dec;44(3):235-49. doi: 10.1007/s12035-011-8196-y. Epub 2011 Jul 5.
MicroRNAs are endogenous non-coding small RNAs that have been described as highly conserved regulators of gene expression. They are involved in cancer and in the regulation of neural development and stem cell function. Recent studies suggest that a small subpopulation of cancer stem cells (CSCs) has the capacity to repopulate solid tumours such as glioblastoma (GBM), drive malignant progression and mediate radio- and chemoresistance. GBM-derived CSCs share the fundamental stem cell properties of self-renewal and multipotency with neural stem cells (NSCs) and may be regulated by miRNAs. In this review, we will summarize the current knowledge regarding the role of miRNAs in GBM development with a focus on the regulation of GBM-CSCs. We propose a list of miRNAs that could serve as molecular classifiers for GBMs and/or as promising therapeutic targets for such brain tumours.
微小 RNA 是内源性非编码的小 RNA，被描述为高度保守的基因表达调控因子。它们参与癌症以及神经发育和干细胞功能的调控。最近的研究表明，一小部分癌症干细胞（CSC）具有重新填充实体瘤（如胶质母细胞瘤（GBM））、驱动恶性进展和介导放射和化学抗性的能力。GBM 衍生的 CSC 与神经干细胞（NSC）具有自我更新和多能性的基本干细胞特性，并且可能受到 miRNAs 的调节。在这篇综述中，我们将总结 miRNA 在 GBM 发展中的作用的最新知识，重点是对 GBM-CSC 的调节。我们提出了一组可能作为 GBM 的分子分类器以及作为此类脑肿瘤有前途的治疗靶点的 miRNA。
