Karczmarek-Borowska Bożenna, Pelc Maria, Rabiej Ewa, Grądalska-Lampart Monika
Pneumonol Alergol Pol. 2014;82(4):349-57. doi: 10.5603/PiAP.2014.0044.
The aim of the study was to assess the influence of non-small cell lung cancer chemotherapy on patients' health status, the occurrence of adverse events and their effect on everyday activities, depending on the patients' sex and age.
The study group consisted of 62 non-small cell lung cancer patients, (21 women and 41 men), aged 51-84 years, hospitalised due to the chemotherapy. The survey included SF-20 test and a questionnaire prepared by the authors.
The most frequent adverse events indicated by the patients were: weakness (79%), nausea and vomiting (77%), loss of appetite (56%) and diarrhoea (45%). It was found that the side-effects of chemotherapy were not dependent on age (p = 0.9882) or sex (p = 0.9968). The chemotherapy negatively influenced the quality of the patients' life (p < 0.000001). It was shown that there is a statistically significant correlation between age and limitations on social roles, professional life and performing housework (p < 0.0133), and also the inability to perform specific types of activities (p < 0.01).
The results of the study show that chemotherapy of non-small cell lung cancer was connected with decreased quality of life, especially in patients over 65 years of age. The patients under 65 years of age could not deal with the disease in respect of psychological aspects, whereas people over 65 years of age had greater problems with physical, social and professional functioning.
本研究旨在评估非小细胞肺癌化疗对患者健康状况、不良事件的发生及其对日常活动的影响，具体取决于患者的性别和年龄。
研究组由62例因化疗住院的非小细胞肺癌患者组成（21名女性和41名男性），年龄在51 - 84岁之间。调查包括SF - 20测试和作者编制的问卷。
患者指出的最常见不良事件为：虚弱（79%）、恶心和呕吐（77%）、食欲不振（56%）和腹泻（45%）。发现化疗的副作用不取决于年龄（p = 0.9882）或性别（p = 0.9968）。化疗对患者的生活质量有负面影响（p < 0.000001）。结果表明，年龄与社会角色、职业生活和家务劳动限制之间存在统计学显著相关性（p < 0.0133），以及无法进行特定类型活动之间也存在显著相关性（p < 0.01）。
研究结果表明，非小细胞肺癌化疗与生活质量下降有关，尤其是65岁以上的患者。65岁以下的患者在心理方面无法应对疾病，而65岁以上的患者在身体、社会和职业功能方面存在更大问题。
