Clifton P G, Barnfield A M, Philcox L
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK.
Psychopharmacology (Berl). 1989;97(1):89-95. doi: 10.1007/BF00443419.
Fluoxetine is a specific and long-lasting inhibitor of serotonin reuptake. In free-feeding rats a dose of 10 mg/kg reduced meal size but had no significant effect on meal frequency. Feeding rate during meals was also reduced. Direct observation of behaviour associated with eating suggested that fluoxetine did not act by enhancing sleep or other behaviour patterns that interfere with eating, although the transition from feeding to sleep occurred more rapidly after drug treatment. Enhancement of satiety or interference with the sustaining of meals by fluoxetine would be consistent with these data. Rebound feeding after anorexia was not observed in either the meal pattern study or in a separate experiment using schedule fed animals. There was also no clear development of tolerance to the anorectic effect of fluoxetine, and we discuss possible reasons for an association of these two properties.
氟西汀是一种特异性且长效的血清素再摄取抑制剂。在自由进食的大鼠中，10毫克/千克的剂量会减小进食量，但对进食频率没有显著影响。进食期间的进食速度也会降低。对与进食相关行为的直接观察表明，氟西汀并非通过增强睡眠或其他干扰进食的行为模式起作用，尽管药物治疗后从进食到睡眠的转变发生得更快。氟西汀增强饱腹感或干扰进食的持续进行与这些数据相符。在进食模式研究或使用定时喂食动物的单独实验中，均未观察到厌食后的反弹性进食。对氟西汀的厌食作用也没有明显的耐受性发展，我们讨论了这两种特性相关联的可能原因。
