Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter , Bucharest-6 , Romania .
J Enzyme Inhib Med Chem. 2015 Apr;30(2):283-5. doi: 10.3109/14756366.2014.915397. Epub 2014 Jun 25.
Stochastic sensing was employed for pattern recognition of HER-1 in biological fluids. Nanostructured materials such as 5,10,15,20-tetraphenyl-21H,23H-porphyrin, maltodextrin and α-cyclodextrin were used to modify diamond paste for stochastic sensing of HER-1. Pattern recognition of HER-1 in biological fluids was performed in a linear concentration range between 5.60 × 10(-11) and 9.72 × 10(-7 )mg ml(-1). The lower limits of determination (10(-12 )mg ml(-1) magnitude order) were recorded when maltodextrin and α-cyclodextrin were used for stochastic sensing. The pattern recognition test of HER-1 in biological fluids samples shows high reliability for both qualitative and quantitative assay.
采用随机传感技术对生物流体中的 HER-1 进行模式识别。采用 5,10,15,20-四苯基-21H,23H-卟啉、麦芽糊精和 α-环糊精等纳米结构材料对金刚石膏进行修饰，用于随机传感 HER-1。在 5.60×10(-11)和 9.72×10(-7)mg/ml(-1)之间的线性浓度范围内对生物流体中的 HER-1 进行模式识别。当使用麦芽糊精和 α-环糊精进行随机传感时，检测限下限（数量级为 10(-12)mg/ml(-1))。生物流体样品中 HER-1 的模式识别测试对定性和定量分析均显示出高度可靠性。
