de Vries R R
Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands.
Rev Infect Dis. 1989 Mar-Apr;11 Suppl 2:S400-3. doi: 10.1093/clinids/11.supplement_2.s400.
Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.
辅助性T淋巴细胞只有在由HLA - II类分子呈递时才能识别分枝杆菌抗原。因此，这些分子可能在针对分枝杆菌的免疫反应调节中发挥重要作用。本文证明，具有不同HLA - II类分子的个体的T细胞对不同的分枝杆菌抗原产生反应。这些数据表明，HLA - II类分子是分枝杆菌免疫反应（Ir）基因的产物。抗分枝杆菌T细胞反应性中这种由基因控制的差异可能解释了某些HLA - II类等位基因与不同的分枝杆菌感染病程之间的关联，并且可能对疫苗开发具有启示意义。
