Liu Yang, Zhai Chengkai, Sun Guiju, Zhang Hong, Jiang Mingxia, Zhang Haifeng, Guo Junling, Lan Xi
Wei Sheng Yan Jiu. 2014 May;43(3):372-7.
To observe and compare the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding induced dyslipidemia rats, and observe its effects on regulation of sterol regulatory element protein-1c (SREBP-1c) mRNA expression in rat liver.
Consolidation 50 SD rats of clean grade feeding adaptation for one week, randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group. Feed with corresponding diets for 8 weeks, and measure the total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), FAS, SREBP-1c mRNA of all groups.
Compared with control group, TC, TG, FBG levels of hyperlipidemia model group were significantly increased (P < 0.05). Compared with model group, TC, TG, FBG levels of grain-bean package group, grain-bean package DF group were significantly decreased, HDL-C levels significantly increased, and activity of FAS, regulation of SREBP-1c were significantly decreased (P < 0.05).
The Grain-bean package dietary fiber can improve blood lipids levels of dyslipidemia rats, and decrease FAS activity and SREBP-1c mRNA expression.
观察并比较谷豆组合包装、谷豆组合包装中提取的膳食纤维（DF）以及谷物玉米中的DF对高脂、高胆固醇喂养诱导的血脂异常大鼠血脂及脂肪酸合酶（FAS）活性的影响，并观察其对大鼠肝脏中固醇调节元件结合蛋白-1c（SREBP-1c）mRNA表达的调控作用。
选取50只清洁级SD大鼠，适应性喂养1周，随机分为正常对照组、高脂血症模型组、谷豆组合包装组、谷豆组合包装DF组和谷物玉米组。给予相应饮食8周，检测各组大鼠的总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、FAS、SREBP-1c mRNA水平。
与对照组相比，高脂血症模型组大鼠的TC、TG、FBG水平显著升高（P<0.05）。与模型组相比，谷豆组合包装组、谷豆组合包装DF组大鼠的TC、TG、FBG水平显著降低，HDL-C水平显著升高，FAS活性及SREBP-1c的调控水平显著降低（P<0.05）。
谷豆组合包装膳食纤维可改善血脂异常大鼠的血脂水平，降低FAS活性及SREBP-1c mRNA表达。
