Minzenberg Michael J, Yoon Jong H, Cheng Yaoan, Carter Cameron S
Department of Psychiatry, University of California, San Francisco School of Medicine, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Department of Psychiatry, Stanford University School of Medicine, and Palo Alto Veterans Affairs Medical Center, Palo Alto, CA, USA.
Neuropsychopharmacology. 2014 Dec;39(13):3018-26. doi: 10.1038/npp.2014.155. Epub 2014 Jun 26.
Control-related cognitive processes such as rule selection are associated with cortical oscillations in the theta, alpha and, beta ranges, and modulated by catecholamine neurotransmission. Thus, a potential strategy for improving cognitive control deficits in schizophrenia would be to use pro-catecholamine pharmacological agents to augment these control-related oscillations. In a double-blind, placebo-controlled (within-subjects) study, we tested the effects of adjunctive single-dose modafinil 200 mg on rule-related 4-30 Hz oscillations in 23 stable schizophrenia patients, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine the power of 4-30 Hz oscillations. Modafinil (relative to placebo) enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with modest effects during rule maintenance. Modafinil treatment in schizophrenia augments middle-frequency cortical oscillatory power associated with rule selection, and may subserve diverse subcomponent processes in proactive cognitive control.
诸如规则选择等与控制相关的认知过程与θ波、α波和β波范围内的皮层振荡相关，并受儿茶酚胺神经传递的调节。因此，改善精神分裂症认知控制缺陷的一种潜在策略是使用促儿茶酚胺类药物来增强这些与控制相关的振荡。在一项双盲、安慰剂对照（受试者内）研究中，我们在23名病情稳定的精神分裂症患者进行认知控制任务时，利用脑电图测试了辅助单剂量200毫克莫达非尼对与规则相关的4 - 30赫兹振荡的影响。脑电图数据采用莫雷小波进行时频分解，以确定4 - 30赫兹振荡的功率。莫达非尼（相对于安慰剂）增强了与θ波、α波和β波范围内高控制规则选择相关的振荡功率，在规则维持期间有适度影响。精神分裂症患者使用莫达非尼治疗可增强与规则选择相关的中频皮层振荡功率，并可能有助于主动认知控制中的多种子成分过程。
