Nakamura K, Kitamura K, Inoue M, Sawada N, Tsugane S
Department of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan,
Osteoporos Int. 2014 Nov;25(11):2565-71. doi: 10.1007/s00198-014-2770-x. Epub 2014 Jun 26.
This study assessed the effects of physical activity on a 10-year incidence of self-reported vertebral fractures in adult women of a large Japanese cohort. Medium levels of strenuous activity and long-duration sedentary activity were associated with a lower incidence of vertebral fractures; association patterns appear to be different from hip fractures.
Physical activity helps prevent hip fracture, but little is known about the longitudinal association between physical activity and vertebral fractures. The purpose of this study was to evaluate the effects of physical activity on the 10-year incidence of symptomatic vertebral fractures using data from the Japan Public Health Center-based Prospective Study.
Baseline studies were conducted in 1993-1994, and the follow-up study was conducted 10 years later. We analyzed 23,757 women aged 40-69 years. At baseline, physical activity was assessed as a predictor by using a questionnaire. Subjects were asked to report vertebral fractures that occurred during the 10-year follow-up period. Relative risks (RRs) adjusted for confounders were estimated by multiple logistic regression analysis.
The 10-year cumulative incidence of vertebral fractures was 0.67%. Those who engaged in strenuous physical activity of <1 h/day had a significantly lower incidence of vertebral fractures than those who did not engage in such activity (RR = 0.52, 95% CI 0.28-0.97), while those engaged in such activity ≥1 h/day did not (RR = 0.82, 95% CI 0.58-1.14). Long-duration sedentary activity was associated with a low incidence of vertebral fractures (P for trend = 0.0002), but the frequencies of sports activities and metabolic equivalents were not (P for trend = 0.0729 and 0.4341, respectively).
Strenuous activity and sedentary activity are associated with the incidence of vertebral fractures, although the association may not be linear. The pattern of association between physical activity and vertebral fractures appears to be different from that of hip fractures.
本研究评估了体力活动对一大群日本成年女性自我报告的椎体骨折10年发病率的影响。中等强度的剧烈活动和长时间久坐活动与较低的椎体骨折发病率相关；关联模式似乎与髋部骨折不同。
体力活动有助于预防髋部骨折，但关于体力活动与椎体骨折之间的纵向关联知之甚少。本研究的目的是利用基于日本公共卫生中心的前瞻性研究数据，评估体力活动对有症状椎体骨折10年发病率的影响。
1993 - 1994年进行基线研究，10年后进行随访研究。我们分析了23757名年龄在40 - 69岁的女性。在基线时，通过问卷调查评估体力活动作为预测因素。受试者被要求报告在10年随访期间发生的椎体骨折情况。通过多因素逻辑回归分析估计调整混杂因素后的相对风险（RRs）。
椎体骨折的10年累积发病率为0.67%。每天进行<1小时剧烈体力活动的人椎体骨折发病率显著低于不进行此类活动的人（RR = 0.52，95% CI 0.28 - 0.97），而每天进行此类活动≥1小时的人则不然（RR = 0.82，95% CI 0.58 - 1.14）。长时间久坐活动与较低的椎体骨折发病率相关（趋势P值 = 0.0002），但体育活动频率和代谢当量则不然（趋势P值分别为0.0729和0.4341）。
剧烈活动和久坐活动与椎体骨折发病率相关，尽管这种关联可能不是线性的。体力活动与椎体骨折之间的关联模式似乎与髋部骨折不同。
