Moriya Shunpei, Tahara Yu, Sasaki Hiroyuki, Hamaguchi Yutaro, Kuriki Daisuke, Ishikawa Ryosuke, Ishigooka Jun, Shibata Shigenobu
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan.
J Pharmacol Sci. 2014;125(3):329-32. doi: 10.1254/jphs.14071sc. Epub 2014 Jun 25.
Circadian rhythms are related to various psychiatric disorders. Recently, antipsychotics, including quetiapine (QTP), have been accepted as potential therapeutic agents for the treatment of depression, but its mechanism remains poorly understood. In this study, we examined clock gene fluctuation patterns in QTP-treated mice. QTP significantly increased Per2 mRNA at ZT12 and Per1 and Per2 expression at ZT18 in the amygdala. There were significant differences between the control and QTP groups in the cross-time effects of Per2 mRNA expression in the amygdala. Our findings suggest that QTP possibly acts on the circadian system, which then induces changes in mood symptoms.
昼夜节律与多种精神疾病有关。最近，包括喹硫平（QTP）在内的抗精神病药物已被公认为治疗抑郁症的潜在治疗药物，但其机制仍知之甚少。在本研究中，我们检测了QTP处理小鼠的生物钟基因波动模式。QTP显著增加了杏仁核中ZT12时的Per2 mRNA以及ZT18时的Per1和Per2表达。杏仁核中Per2 mRNA表达的交叉时间效应在对照组和QTP组之间存在显著差异。我们的研究结果表明，QTP可能作用于昼夜节律系统，进而引起情绪症状的变化。
