Zhao Hong-Yu, Wang Rui, Ma Wei
Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.
J BUON. 2014 Apr-Jun;19(2):562-6.
The association between Interleukin-17A (IL- 17A) G197A and IL-17F T7488C polymorphisms and risk for specific forms of cancer is inconclusive. We conducted a meta-analysis of all published studies to estimate the association of IL-17A G197A and IL-17F T7488C polymorphisms and cancer risk.
A systematic computerized searching of the PubMed and Web of Science databases was performed for relevant publications. Data were extracted and statistical analysis was performed using RevMan 5.2 software.
Eight eligible case-control studies with 3,323 cases and 3,974 controls were included into this meta-analysis. The pooled odds ratios (ORs) showed that the IL-17A G197A polymorphism increased the risk for specific forms of cancer under the following genetic models: A vs G (OR = 1.31, 95 % CI 1.13-1.52, Ph - 0.02); AA vs GG (OR = 1.81, 95 % CI 1.30- 2.52, Ph = 0.007); AA /AG vs GG (OR = 1.26, 95 % CI 1.11- 1.43, Ph = 0.79); AA vs AG / GG (OR = 1.72, 95 % CI 1.16-2.53, Ph <0.0001). However, the IL-17F T7488C polymorphism did not increase or decrease cancer risk under all genetic models. Stratified analysis by cancer type revealed that the IL-17A G197A polymorphism may increase the risk of gastric cancer. Further subgroup analysis by country indicated that there was a statistically increased cancer risk in China.
The present meta-analysis showed the IL- 17A G197A polymorphism is associated with a significantly increased risk for specific forms of cancer, especially in gastric cancer. Subsequent studies with large sample size are warranted to validate this association.
白细胞介素-17A（IL-17A）G197A和白细胞介素-17F（IL-17F）T7488C基因多态性与特定癌症形式风险之间的关联尚无定论。我们对所有已发表的研究进行了荟萃分析，以评估IL-17A G197A和IL-17F T7488C基因多态性与癌症风险的关联。
通过计算机系统检索PubMed和Web of Science数据库以获取相关出版物。提取数据并使用RevMan 5.2软件进行统计分析。
本荟萃分析纳入了8项符合条件的病例对照研究，共3323例病例和3974例对照。合并比值比（OR）显示，在以下遗传模型下，IL-17A G197A基因多态性增加了特定癌症形式的风险：A与G相比（OR = 1.31，95%CI 1.13 - 1.52，P = 0.02）；AA与GG相比（OR = 1.81，95%CI 1.30 - 2.52，P = 0.007）；AA/AG与GG相比（OR = 1.26，95%CI 1.11 - 1.43，P = 0.79）；AA与AG/GG相比（OR = 1.72，95%CI 1.16 - 2.53，P <0.0001）。然而，在所有遗传模型下，IL-17F T7488C基因多态性均未增加或降低癌症风险。按癌症类型进行的分层分析显示，IL-17A G197A基因多态性可能增加胃癌风险。按国家进行的进一步亚组分析表明，在中国癌症风险有统计学意义的增加。
本荟萃分析表明，IL-17A G197A基因多态性与特定癌症形式的风险显著增加相关，尤其是在胃癌中。需要后续大样本量研究来验证这种关联。
