Feng Bing, Fan Yonggang, Wang Wei, Yao Guoliang, Zhai Jingming
Department of General Surgery, The First Affiliated Hospital of Henan Science and Technology University, Luoyang, 471000, Henan Province, China,
Tumour Biol. 2014 Oct;35(10):9977-85. doi: 10.1007/s13277-014-2288-z. Epub 2014 Jul 10.
Interleukin 17A (IL-17A) is a critical cytokine involved in inflammatory diseases and inflammation-associated cancers. Increasing case-control studies have implicated crucial roles of IL-17A single nucleotide polymorphisms (G197A and C1249T) in gastric carcinogenesis, but providing inconclusive findings. The present study is aimed to estimate the association of IL-17A G197A and C1249T polymorphisms with gastric cancer risk by pooling all available publications. A comprehensive literature search in PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases was performed for eligible publications from their inception up to May 5, 2014. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were calculated to estimate the effect of IL-17A polymorphisms on gastric carcinogenesis. Stratified analysis by ethnicity, Helicobacter pylori (H. pylori) infection, and smoking status were also conducted. All analyses were performed by using the Stata 12.0 software. There were five case-control studies with 2,774 cases and 3,162 controls and two case-control studies with 620 cases and 1,123 controls on the susceptibility of IL-17A G197A and C1249T polymorphisms to gastric cancer, respectively. Significant association was observed between IL-17A G197A polymorphism and gastric cancer risk, particularly among Asians. The status of H. pylori infection and smoking did not influence this association. In addition, the IL-17A C1249T polymorphism did not confer a risk effect on gastric carcinogenesis. The pooled results were not materially altered by sensitivity analysis. We firstly show that the polymorphism of IL-17A G197A but not C1249T is a risk factor for gastric cancer.
白细胞介素17A（IL-17A）是一种参与炎症性疾病和炎症相关癌症的关键细胞因子。越来越多的病例对照研究表明，IL-17A单核苷酸多态性（G197A和C1249T）在胃癌发生过程中起关键作用，但研究结果尚无定论。本研究旨在通过汇总所有可用的出版物来评估IL-17A G197A和C1249T多态性与胃癌风险之间的关联。在PubMed、Embase、Web of Science、中国知网（CNKI）和万方数据库中进行了全面的文献检索，以获取从数据库建立至2014年5月5日符合条件的出版物。计算合并优势比（OR）及相应的95%置信区间（CI），以评估IL-17A多态性对胃癌发生的影响。还按种族、幽门螺杆菌（H. pylori）感染情况和吸烟状况进行了分层分析。所有分析均使用Stata 12.0软件进行。分别有五项病例对照研究（共2774例病例和3162例对照）以及两项病例对照研究（共620例病例和1123例对照）探讨了IL-17A G197A和C1249T多态性对胃癌的易感性。观察到IL-17A G197A多态性与胃癌风险之间存在显著关联，尤其是在亚洲人群中。幽门螺杆菌感染状况和吸烟情况并未影响这种关联。此外，IL-17A C1249T多态性对胃癌发生没有风险影响。敏感性分析未对合并结果产生实质性改变。我们首次表明，IL-17A G197A而非C1249T的多态性是胃癌的一个风险因素。
