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白细胞介素-17A基因G197A多态性与胃癌风险的关联：基于6624例病例和7631例对照的最新荟萃分析

Association between IL-17A G197A polymorphism and gastric cancer risk: an updated meta-analysis based on 6,624 cases and 7,631 controls.

作者信息

Hu Lixia, Kong Fanliang, Pan Yueyin

机构信息

Department of Oncology, The Second People's Hospital of Hefei, Hefei, Anhui, China.

Department of Oncology, Anhui Province Hospital, Hefei, Anhui, China.

出版信息

Onco Targets Ther. 2018 Feb 5;11:703-710. doi: 10.2147/OTT.S151129. eCollection 2018.

DOI:10.2147/OTT.S151129
PMID:29440917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5804291/
Abstract

PURPOSE

Previous studies investigating the association between interleukin-17A (IL-17A) G197A polymorphism and gastric cancer risk have provided inconsistent results. We, therefore, conducted this meta-analysis to clarify the association between IL-17A G197A polymorphism and gastric cancer risk.

METHODS

We searched PubMed, Excerpta Medica Database, and CNKI databases to identify relevant studies up to June 10, 2017. A total of 16 case-control studies including 6,624 cases and 7,631 controls were identified.

RESULTS

Overall, significant associations between IL-17A G197A polymorphism and gastric cancer risk were observed (A vs G: OR =1.24, 95% CI =1.14-1.36; AA vs GG: OR =1.63, 95% CI =1.35-1.96; GA vs GG: OR =1.12, 95% CI =1.01-1.25; AA+GA vs GG: OR =1.23, 95% CI =1.11-1.35; AA vs GA+GG: OR =1.54, 95% CI =1.27-1.87). Similar associations were also observed in Asian population (A vs G: OR =1.25, 95% CI =1.15-1.37; AA vs GG: OR =1.62, 95% CI =1.33-1.97; GA vs GG: OR =1.16, 95% CI =1.07-1.25; AA+GA vs GG: OR =1.24, 95% CI =1.15-1.33; AA vs GA+GG: OR =1.51, 95% CI =1.23-1.85), in Caucasian population (AA vs GA+GG: OR =2.19, 95% CI =1.40-3.44), and in the hospital-based controls' subgroup (A vs G: OR =1.30, 95% CI =1.17-1.45; AA vs GG: OR =1.81, 95% CI =1.46-2.25; AA+GA vs GG: OR =1.27, 95% CI =1.12-1.43; AA vs GA+GG: OR =1.71, 95% CI =1.34-2.18).

CONCLUSIONS

The current meta-analysis suggests that IL-17A G197A polymorphism might enhance gastric cancer risk.

摘要

目的

既往研究探讨白细胞介素 - 17A（IL - 17A）基因G197A多态性与胃癌风险之间的关联，结果并不一致。因此，我们进行了这项荟萃分析，以阐明IL - 17A基因G197A多态性与胃癌风险之间的关联。

方法

我们检索了PubMed、医学文摘数据库和中国知网数据库，以识别截至2017年6月10日的相关研究。共纳入16项病例对照研究，包括6624例病例和7631例对照。

结果

总体而言，观察到IL - 17A基因G197A多态性与胃癌风险之间存在显著关联（A与G比较：比值比[OR]=1.24，95%可信区间[CI]=1.14 - 1.36；AA与GG比较：OR =1.63，95%CI =1.35 - 1.96；GA与GG比较：OR =1.12，95%CI =1.01 - 1.25；AA + GA与GG比较：OR =1.23，95%CI =1.11 - 1.35；AA与GA + GG比较：OR =1.54，95%CI =1.27 - 1.87）。在亚洲人群（A与G比较：OR =1.25，95%CI =1.15 - 1.37；AA与GG比较：OR =1.62，95%CI =1.33 - 1.97；GA与GG比较：OR =1.16，95%CI =1.07 - 1.25；AA + GA与GG比较：OR =1.24，95%CI =1.15 - 1.33；AA与GA + GG比较：OR =1.51，95%CI =1.23 - 1.85）、高加索人群（AA与GA + GG比较：OR =2.19，95%CI =1.40 - 3.44）以及基于医院对照的亚组（A与G比较：OR =1.30，95%CI =1.17 - 1.45；AA与GG比较：OR =1.81，95%CI =1.46 - 2.25；AA + GA与GG比较：OR =1.27，95%CI =1.12 - 1.43；AA与GA + GG比较：OR =1.71，95%CI =1.34 -

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14bc/5804291/d6077bab13b9/ott-11-703Fig8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14bc/5804291/61d87f5d1d49/ott-11-703Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14bc/5804291/090b5aa32add/ott-11-703Fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14bc/5804291/d6077bab13b9/ott-11-703Fig8.jpg

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