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斯佩拉定F-H,三种源自海洋真菌米曲霉的新型氧化吲哚生物碱。

Speradines F-H, three new oxindole alkaloids from the marine-derived fungus Aspergillus oryzae.

作者信息

Hu Xiao, Xia Qi-Wen, Zhao Yang-Yang, Zheng Qiu-Hong, Liu Qin-Ying, Chen Li, Zhang Qi-Qing

机构信息

Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University.

出版信息

Chem Pharm Bull (Tokyo). 2014;62(9):942-6. doi: 10.1248/cpb.c14-00312. Epub 2014 Jun 26.

Abstract

A rare hexacyclic oxindole alkaloid, speradine F (1), together with two novel tetracyclic oxindole alkaloids, speradines G (2) and H (3), were isolated from the marine-derived fungus Aspergillus oryzae. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. This study is the first report on cyclopiazonic acid (CPA)-type alkaloids with a hexacyclic skeleton.

摘要

从海洋来源的米曲霉中分离出一种罕见的六环氧化吲哚生物碱——螺环丁烷F(1),以及两种新型四环氧化吲哚生物碱——螺环丁烷G(2)和H(3)。它们的结构通过光谱方法和X射线衍射分析确定。本研究是关于具有六环骨架的环匹阿尼酸(CPA)型生物碱的首次报道。

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