Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Mar Drugs. 2020 Jan 14;18(1):54. doi: 10.3390/md18010054.
Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.
氮杂环化合物因其显著的生物活性而引起了相当大的关注。生活在极端环境中的海洋真菌是这些基本含氮次生代谢产物的最丰富来源之一。作为最著名的丝状真菌通用群体之一，海洋来源的 种产生了大量结构独特的杂环生物碱。本综述试图全面总结海洋来源的 种产生的杂环生物碱的结构多样性和生物活性。本文共收录了自 2014 年初至 2018 年底报道的 130 种此类结构，引用了 75 篇参考文献，这将有助于未来的药物开发和创新。
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