在计算机上寻找人类基因组中用于多梳抑制复合物2拴系的假定顺式作用元件。
In silico finding of Putative Cis-Acting Elements for the Tethering of Polycomb Repressive Complex2 in Human Genome.
作者信息
Hajjari Mohammadreza, Behmanesh Mehrdad, Jahani Mohammad Mehdi
机构信息
Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz, Iran ; Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
出版信息
Bioinformation. 2014 Apr 23;10(4):187-90. doi: 10.6026/97320630010187. eCollection 2014.
Polycomb Repressive Complex2 maintains a predetermined state of transcription which constitutes a cellular memory stable over many cell divisions. Since this complex acts through the regulation of chromatin structure, it is important to understand how it is recruited to chromatin. The specific target sequences of this complex such as PRE (polycomb repressive element) have not been completely recognized in human genome. In this study, we have compared the target sequences of this complex with non-target genes in tumor cell lines. Through in silico and statistical analyses, we have identified some motifs which are over-represented in target genes against non-target genes. Analyzing these motifs shows some transcription factors which are potential recruiters of Polycomb repressive complex2.
多梳抑制复合物2维持着一种预先确定的转录状态，这种状态构成了在许多细胞分裂过程中稳定的细胞记忆。由于该复合物通过染色质结构的调节发挥作用，因此了解它如何被招募到染色质上很重要。该复合物的特定靶序列，如多梳抑制元件（PRE），在人类基因组中尚未被完全识别。在本研究中，我们比较了该复合物在肿瘤细胞系中的靶序列与非靶基因。通过计算机模拟和统计分析，我们确定了一些在靶基因中相对于非靶基因过度富集的基序。对这些基序的分析揭示了一些可能是多梳抑制复合物2招募者的转录因子。
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