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长链非编码RNA:通过这些方法表征基因座特征。

Long Non-coding RNA: Characterizing the Locus Features by the Approaches.

作者信息

Hajjari Mohammadreza, Rahnama Saghar

机构信息

Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz 61336-3337, Iran.

出版信息

Genomics Inform. 2017 Dec;15(4):170-177. doi: 10.5808/GI.2017.15.4.170. Epub 2017 Dec 29.

Abstract

is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the gene encoding . Therefore, understanding the molecular mechanism and its regulation remains to be challenging. We used different analyses to find genetic and epigenetic elements of gene to gain insight into its regulation. We reported different regulatory elements including canonical promoters, transcription start sites, CpGIs as well as epigenetic marks that are potentially involved in the regulation of gene expression. We identified repeat sequences and single nucleotide polymorphisms that are located within or next to the CpGIs of . Our analyses may help to find potential interactions between genetic and epigenetic elements of gene in the human tissues and show opportunities and limitations for researches on gene in future studies.

摘要

是一种已知在不同癌症中具有致癌作用的长链非编码RNA。对于编码该基因的遗传和表观遗传元件及其相互作用的了解有限。因此,了解其分子机制及其调控仍然具有挑战性。我们使用了不同的分析方法来寻找该基因的遗传和表观遗传元件,以深入了解其调控机制。我们报告了不同的调控元件,包括典型启动子、转录起始位点、CpG岛以及可能参与该基因表达调控的表观遗传标记。我们鉴定了位于该基因CpG岛内部或旁边的重复序列和单核苷酸多态性。我们的分析可能有助于发现人体组织中该基因的遗传和表观遗传元件之间的潜在相互作用,并为未来关于该基因的研究展示机会和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb7/5769859/50fa9982c28a/gi-15-4-170f1.jpg

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