Cao Na, Chen Tao, Guo Zai-Pei, Li Meng-Meng, Jiao Xiao-Yan
Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Ann Dermatol. 2014 Jun;26(3):303-7. doi: 10.5021/ad.2014.26.3.303. Epub 2014 Jun 12.
Henoch-Schönlein purpura (HSP) is an immune complex-mediated disease predominantly characterized by the deposition of circulating immune complexes containing immunoglobulin A (IgA) on the walls of small vessels. Although the pathogenesis of HSP is not yet fully understood, some researchers proposed that B-cell activation might play a critical role in the development of this disease.
To investigate the serum levels of visfatin (pre-B-cell colony-enhancing factor), B-cell-activating factor (BAFF), and CXCL13, and to analyze their association with disease severity.
The serum levels of visfatin, BAFF, and CXCL13 were measured by using a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 43 patients with HSP and 45 controls. The serum levels of IgA anticardiolipin antibodies (ACA) were detected by using a double-antigen sandwich ELISA.
Levels of visfatin but not BAFF and CXCL13 were significantly elevated in the sera of patients with HSP in the acute stage, and restored to normal levels in the convalescent stage. Furthermore, serum levels of visfatin were significantly higher in patients with HSP having renal involvement than in those without renal involvement. Serum levels of visfatin were correlated with the severity of HSP and serum concentration of ACA-IgA.
We show for the first time that the serum levels of visfatin are abnormally elevated in patients with HSP. Visfatin may be associated with the pathogenesis of HSP.
过敏性紫癜（HSP）是一种免疫复合物介导的疾病，主要特征是含有免疫球蛋白A（IgA）的循环免疫复合物沉积在小血管壁上。尽管HSP的发病机制尚未完全明确，但一些研究人员提出B细胞活化可能在该疾病的发展中起关键作用。
研究内脂素（前B细胞集落增强因子）、B细胞活化因子（BAFF）和CXCL13的血清水平，并分析它们与疾病严重程度的关系。
采用双抗体夹心酶联免疫吸附测定（ELISA）法检测43例HSP患者和45例对照者血清内脂素、BAFF和CXCL13水平。采用双抗原夹心ELISA法检测血清IgA抗心磷脂抗体（ACA）水平。
急性期HSP患者血清内脂素水平显著升高，而BAFF和CXCL13水平无明显变化，恢复期恢复至正常水平。此外，有肾脏受累的HSP患者血清内脂素水平显著高于无肾脏受累者。血清内脂素水平与HSP严重程度及ACA-IgA血清浓度相关。
我们首次表明HSP患者血清内脂素水平异常升高。内脂素可能与HSP的发病机制有关。
