Lin Yiwei, Zhou Binhua P
Departments of Molecular and Cellular Biochemistry, and Markey Cancer Center, College of Medicine, The University of Kentucky, Lexington, KY 40506, USA.
Front Biol (Beijing). 2013 Apr 1;8(2):228-233. doi: 10.1007/s11515-012-1211-5.
Epigenetic deregulation is intimately associated with the development of human diseases. Intensive studies are currently underway to clarify the mechanism for the sake of achieving ideal diagnostic and therapeutic goals. It has been demonstrated that enzymes with histone-modifying activities can also target non-histone proteins, with the underlying mechanism remaining obscure. In this review, we focus on a novel histone mimicry strategy that may be wildly adapted during the non-histone substrate recognition process. Its potential clinical implications are also discussed.
表观遗传失调与人类疾病的发展密切相关。目前正在进行深入研究以阐明其机制，以期实现理想的诊断和治疗目标。已经证明，具有组蛋白修饰活性的酶也可以作用于非组蛋白，但其潜在机制仍不清楚。在本综述中，我们关注一种可能在非组蛋白底物识别过程中广泛适用的新型组蛋白模拟策略。我们还讨论了其潜在的临床意义。
