Liang Yan-Fang, Zeng Jin-Cheng, Ruan Jian-Bo, Kang Dong-Ping, Wang Ling-Mei, Chen Can, Xu Jun-Fa, Wu Qiu-Liang
Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Dongguan, 523808, China.
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2654-7. eCollection 2014.
In this article, we described a malignant myoepithelioma of the breast (MMB) in a 69-year-old woman. Breast cancer derived from myoepithelial cells is very rare, usually benign. The diagnosis of MMB based on histological and immunohistochemical finding. In this case, the author diagnosed the tumor as MMB, because tumor tissues were immunopositive for 34βE12, P63, SMA, S-100, CD10, E-Cad and Ki-67, and immunnegative for CK5/6, desmin, ER, PR and C-erbB-2, because tumor tissue showed invasive growth and local hemorrhage or necrosis, suggesting malignant, and also because there was a transition between the tumor cells and hyperplastic myoepithelium of non-tumorous ducts. The patient's postoperative recovery is smooth and regular following of patient is essential.
在本文中，我们描述了一名69岁女性的乳腺恶性肌上皮瘤（MMB）。源自肌上皮细胞的乳腺癌非常罕见，通常为良性。MMB的诊断基于组织学和免疫组化结果。在该病例中，作者将肿瘤诊断为MMB，因为肿瘤组织对34βE12、P63、平滑肌肌动蛋白（SMA）、S-100、CD10、E-钙黏蛋白（E-Cad）和Ki-67呈免疫阳性，而对细胞角蛋白5/6（CK5/6）、结蛋白、雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（C-erbB-2）呈免疫阴性，因为肿瘤组织显示浸润性生长以及局部出血或坏死，提示为恶性，还因为肿瘤细胞与非肿瘤性导管的增生性肌上皮之间存在过渡。患者术后恢复顺利且规律，对患者的随访至关重要。
