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异佛手柑内酯对乳腺癌和前列腺癌细胞系的抗增殖评估。

Antiproliferative evaluation of isofuranodiene on breast and prostate cancer cell lines.

作者信息

Buccioni Michela, Dal Ben Diego, Lambertucci Catia, Maggi Filippo, Papa Fabrizio, Thomas Ajiroghene, Santinelli Claudia, Marucci Gabriella

机构信息

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1 62032 Camerino, Italy.

出版信息

ScientificWorldJournal. 2014;2014:264829. doi: 10.1155/2014/264829. Epub 2014 May 22.

DOI:10.1155/2014/264829
PMID:24967427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4055639/
Abstract

The anticancer activity of isofuranodiene, extracted from Smyrnium olusatrum, was evaluated in human breast adenocarcinomas MDA-MB 231 and BT 474, and Caucasian prostate adenocarcinoma PC 3 cell lines by MTS assay. MTS assay showed a dose-dependent growth inhibition in the tumor cell lines after isofuranodiene treatment. The best antiproliferative activity of the isofuranodiene was found on PC 3 cells with an IC50 value of 29 μM, which was slightly less than the inhibition against the two breast adenocarcinoma cell lines with IC50 values of 59 and 55 μM on MDA-MB 231 and BT 474, respectively. Hoechst 33258 assay was performed in order to study the growth inhibition mechanism in prostate cancer cell line; the results indicate that isofuranodiene induces apoptosis. Overall, the understudy compound has a good anticancer activity especially towards the PC 3. On the contrary, it is less active on Chinese hamster ovary cells (CHO) and human embryonic kidney (HEK 293) appearing as a good candidate as a potential natural anticancer drug with low side effects.

摘要

采用MTS法，对从香芹中提取的异呋喃二烯在人乳腺腺癌MDA - MB 231和BT 474以及高加索人前列腺腺癌PC 3细胞系中的抗癌活性进行了评估。MTS法显示，异呋喃二烯处理后，肿瘤细胞系的生长受到剂量依赖性抑制。异呋喃二烯对PC 3细胞的抗增殖活性最佳，IC50值为29 μM，略低于对两种乳腺腺癌细胞系的抑制作用，MDA - MB 231和BT 474的IC50值分别为59 μM和55 μM。为研究前列腺癌细胞系的生长抑制机制，进行了Hoechst 33258检测；结果表明异呋喃二烯可诱导细胞凋亡。总体而言，所研究的化合物具有良好的抗癌活性，尤其是对PC 3细胞。相反，它对中国仓鼠卵巢细胞（CHO）和人胚肾细胞（HEK 293）的活性较低，有望成为一种潜在的低副作用天然抗癌药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/0490fc76a736/TSWJ2014-264829.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/eb09b6a39358/TSWJ2014-264829.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/788833911b82/TSWJ2014-264829.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/6ca1f68a6e35/TSWJ2014-264829.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/5dca7f23d28e/TSWJ2014-264829.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/0490fc76a736/TSWJ2014-264829.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/eb09b6a39358/TSWJ2014-264829.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/788833911b82/TSWJ2014-264829.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/6ca1f68a6e35/TSWJ2014-264829.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/5dca7f23d28e/TSWJ2014-264829.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a115/4055639/0490fc76a736/TSWJ2014-264829.005.jpg

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