从海洋海绵 Acanthostrongylophora ingens 中分离得到具有新型曼沙宁骨架的棘曼沙宁 A-E。

Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens.

机构信息

Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

出版信息

Org Lett. 2014 Aug 1;16(15):3888-91. doi: 10.1021/ol5015569. Epub 2014 Jun 26.

Abstract

Five new manzamine alkaloids, acanthomanzamines A-E, were isolated from the marine sponge Acanthostrongylophora ingens. Acanthomanzamines A and B are the first examples, containing a tetrahydroisoquinoline instead of a β-carboline in manzamine-related alkaloids. Acanthomanzamine C contains a hexahydrocyclopenta[b]pyrrol-4(2H)-one ring that may be converted from an eight-membered ring in manzamine A. Acanthomanzamines D and E have an additional oxazolidine and 2-methyloxazolidine rings, respectively, which fuse to the manzamine skeleton.

摘要

从海洋海绵 Acanthostrongylophora ingens 中分离得到了五个新的曼扎明生物碱，分别命名为 acanthomanzamines A-E。Acanthomanzamines A 和 B 是第一个含有四氢异喹啉而不是 β-咔啉的曼扎明相关生物碱的例子。Acanthomanzamine C 含有一个六氢环戊[b]吡咯-4(2H)-酮环，可能是由曼扎明 A 中的八元环转化而来。Acanthomanzamines D 和 E 分别含有一个噁唑烷和 2-甲基噁唑烷环，它们分别与曼扎明骨架融合。