Kubota Takaaki, Nakamura Kenta, Kurimoto Shin-Ichiro, Sakai Kanae, Fromont Jane, Gonoi Tohru, Kobayashi Jun'ichi
Showa Pharmaceutical University , 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
J Nat Prod. 2017 Apr 28;80(4):1196-1199. doi: 10.1021/acs.jnatprod.6b01110. Epub 2017 Feb 16.
A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2'-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.
从冲绳的一种海绵（Amphimedon sp.）中分离出一种新的曼赞明生物碱——扎马米定D（1）。基于光谱数据阐明了扎马米定D（1）的结构，包括其相对构型。扎马米定D（1）是首个以2,2'-亚甲基双色胺单元作为芳香部分而非β-咔啉单元的曼赞明生物碱。扎马米定D（1）对几种细菌和真菌显示出抗菌活性。
