Department of Economics, City University London, London, UK.
GlaxoSmithKline PLC, Uxbridge, UK.
Value Health. 2014 Jun;17(4):372-9. doi: 10.1016/j.jval.2014.03.002. Epub 2014 May 3.
Governments are turning their attention to evidence on subjective measures of well-being to inform policy decisions. In the context of health, there is, therefore, growing interest in understanding how measures of health-related quality of life relate to subjective well-being and whether subjective well-being could provide a basis for resource allocation decisions in the future. This study investigates the relationship between health-related quality of life, as measured by the EuroQol five-dimensional (EQ-5D) questionnaire, and subjective well-being in Parkinson's disease.
A paper questionnaire including the EQ-5D questionnaire, four key subjective well-being questions taken from the Integrated Household Survey in England, and other demographic details was distributed to people with Parkinson's disease in the United Kingdom. Responses were used to estimate multiple regression models explaining subjective well-being using the EQ-5D questionnaire index (UK weights), EQ-5D questionnaire dimensions and the visual analogue scale, and patients' sociodemographic characteristics.
A total of 199 responses were received. Combining visual analogue scale and EQ-5D questionnaire dimensions, especially anxiety/depression and, to a lesser extent, mobility, yielded the best-fitting models (adjusted R(2) range 0.36-0.53). Patients with Parkinson's disease living in care homes report lower levels of subjective well-being than do those living alone. These effects are not captured by the health-related quality-of-life measures in the analysis.
Usual health-related quality-of-life measures can partially explain different well-being dimensions, yet they fail to capture part of the broader impact of disease on subjective well-being. Further empirical research into the relationship between subjective well-being and the EQ-5D Parkinson's disease longitudinally, and in different disease areas, is required, and further standardization of subjective well-being measures is recommended.
政府正在关注主观幸福感的证据，以为政策决策提供信息。因此，在健康方面，人们越来越感兴趣的是了解健康相关生活质量测量与主观幸福感的关系，以及主观幸福感是否可以为未来的资源分配决策提供依据。本研究调查了帕金森病患者健康相关生活质量（通过欧洲五维健康量表（EQ-5D）问卷测量）与主观幸福感之间的关系。
在英国，向帕金森病患者发放了一份纸质问卷，其中包括 EQ-5D 问卷、来自英格兰综合家庭调查的四个关键主观幸福感问题以及其他人口统计学细节。使用这些回答来估计多元回归模型，使用 EQ-5D 问卷指数（英国权重）、EQ-5D 问卷维度和视觉模拟量表以及患者的社会人口统计学特征来解释主观幸福感。
共收到 199 份回复。将视觉模拟量表和 EQ-5D 问卷维度结合起来，特别是焦虑/抑郁，在较小程度上还有行动能力，产生了拟合度最佳的模型（调整后的 R²范围为 0.36-0.53）。住在养老院的帕金森病患者报告的主观幸福感水平低于独居患者。这些影响在分析中未被健康相关生活质量测量所捕捉到。
常用的健康相关生活质量测量可以部分解释不同的幸福感维度，但它们未能捕捉到疾病对主观幸福感的更广泛影响。需要进一步进行主观幸福感与 EQ-5D 帕金森病的关系的实证研究，包括纵向研究和不同疾病领域的研究，并建议进一步标准化主观幸福感的测量。
