注意缺陷多动障碍（ADHD）患者血清新蝶呤水平升高。
Increased levels of serum neopterin in attention deficit/hyperactivity disorder (ADHD).
作者信息
Ceylan Mehmet Fatih, Uneri Ozden Sukran, Guney Esra, Ergin Merve, Alisik Murat, Goker Zeynep, Senses Dinc Gulser, Karaca Kara Fatma, Erel Ozcan
机构信息
Yildirim Beyazit University Faculty of Medicine, Child and Adolescent Psychiatry Department, Ankara, Turkey.
Ankara Pediatric &Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey.
出版信息
J Neuroimmunol. 2014 Aug 15;273(1-2):111-4. doi: 10.1016/j.jneuroim.2014.06.002. Epub 2014 Jun 14.
Attention deficit/hyperactivity disorder (ADHD) is the most frequently occurring neuropsychiatric disorder in childhood with an etiology that is not fully understood. A number of reviews that have addressed the neurobiology of ADHD have focused on imaging and genetics. Relatively little attention has been given to factors/mechanisms involved in the brain dysfunction. We suggest that changes in cellular immunity may be involved. Neopterin is a good indicator of cellular immunity, and we evaluated serum levels of neopterin in patients with ADHD. The study group consisted of 49 patients with ADHD. An age- and gender-matched control group was composed of 31 healthy subjects. Venous blood samples were collected, and the levels of neopterin were measured. The levels of neopterin were significantly higher in ADHD than in the comparison subjects. Cellular immunity may have a role in the etiopathogenesis of ADHD.
注意缺陷多动障碍（ADHD）是儿童期最常见的神经精神疾病，其病因尚未完全明确。许多关于ADHD神经生物学的综述都集中在影像学和遗传学方面。相对而言，对大脑功能障碍所涉及的因素/机制关注较少。我们认为细胞免疫的变化可能与之有关。新蝶呤是细胞免疫的一个良好指标，我们评估了ADHD患者的血清新蝶呤水平。研究组由49例ADHD患者组成。一个年龄和性别匹配的对照组由31名健康受试者组成。采集静脉血样本并测量新蝶呤水平。ADHD患者的新蝶呤水平显著高于对照受试者。细胞免疫可能在ADHD的病因发病机制中起作用。
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