Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, United States.
Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, United States.
Psychoneuroendocrinology. 2019 Nov;109:104408. doi: 10.1016/j.psyneuen.2019.104408. Epub 2019 Aug 13.
There has been mounting interest in the pathophysiological relation between inflammation and psychopathology. In this paper, we examined associations between internalizing and externalizing psychopathology and inflammation in adolescents with a history of severe psychosocial deprivation and children reared in typical family contexts.
The Bucharest Early Intervention Project is a longitudinal randomized trial of high-quality foster care as an alternative to institutional care. This report is based on 56 institutionalized children randomized to care as usual, 59 institutionalized children randomized to foster care, and 101 never institutionalized children who were recruited as an in-country comparison sample. Externalizing and internalizing behaviors were reported by parents and teachers at ages 8, 12, and 16. At age 16, C-reactive protein (CRP) was derived from blood spots in a subset of participants (n = 127). Multiple-group latent growth curve models were used to examine externalizing and internalizing trajectories and their associations with CRP.
Among children assigned to care as usual, higher levels of externalizing behaviors at age 8, as well as smaller decreases in these behaviors from 8 to 16 years predicted higher levels of CRP at age 16. In the same group of children, higher internalizing behaviors at age 8, but not the rate of change in these behaviors, also predicted higher levels of CRP. In contrast, these relations were not observed in the children assigned to foster care and never institutionalized controls.
Early institutional rearing is associated with a coupling of psychopathology and inflammation, whereas early placement into foster care buffers against these risks. These findings have implications for promoting healthy mental and physical development amongst institutionalized children.
炎症与精神病理学之间的病理生理关系引起了越来越多的关注。在本文中，我们研究了有严重心理社会剥夺史的青少年和在典型家庭环境中成长的儿童的内化和外化精神病理学与炎症之间的关联。
布加勒斯特早期干预项目是一项高质量寄养替代机构照顾的纵向随机试验。本报告基于以下三组数据：23 名被随机分配到常规护理的机构化儿童、25 名被随机分配到寄养的机构化儿童和 101 名从未被机构化的儿童，他们被招募为国内比较样本。父母和老师在 8、12 和 16 岁时报告了外化和内化行为。在 16 岁时，从一部分参与者（n=127）的血斑中提取 C 反应蛋白（CRP）。使用多组潜在增长曲线模型来检查外化和内化轨迹及其与 CRP 的关系。
在被分配到常规护理的儿童中，8 岁时的外化行为水平较高，以及从 8 岁到 16 岁期间这些行为的减少幅度较小，预测了 16 岁时 CRP 水平较高。在同一组儿童中，8 岁时的内化行为水平较高，但这些行为的变化率与 CRP 水平没有关系。相比之下，在被分配到寄养的儿童和从未被机构化的对照组中，没有观察到这些关系。
早期机构抚养与精神病理学和炎症的结合有关，而早期安置在寄养家庭中可以缓冲这些风险。这些发现对促进机构化儿童的身心健康发展具有重要意义。
