Department of Medical Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China.
Oncology. 2014;87(1):40-7. doi: 10.1159/000362670. Epub 2014 Jun 25.
Elevated serum beta-2 microglobulin (β2-M) has previously been reported in non-Hodgkin lymphoma (NHL) patients. This study examined the association between serum β2-M and the prognosis of NHL and analyzed its predictive value.
A total of 287 NHL patients from Taiyuan, Shanxi, China, participated in a prospective cohort study between 2008 and 2011. Overall survival (OS) was compared between NHL patients with high and normal β2-M levels using the log-rank test. Three standard Cox regression models including the International Prognostic Index (IPI) score, β2-M or IPI score+β2-M as independent variables were constructed. The time-dependent receiver operating characteristic curves method and C index were used to examine the tendency of the models' predictive accuracy over time.
NHL patients with elevated β2-M values had worse OS (p<0.001) and higher mortality risk (HR=1.93, 95% CI 1.37-2.77, p<0.001) than patients with normal β2-M values. There were statistically significant differences between the C indexes for the models with IPI+β2-M, IPI or β2-M alone (p<0.001).
Our results demonstrated an association between serum β2-M and NHL prognosis. Combining β2-M with IPI may help to improve the prognostic accuracy of NHL.
β2-微球蛋白（β2-M）在非霍奇金淋巴瘤（NHL）患者中已有报道。本研究探讨了血清β2-M 与 NHL 预后之间的关系，并分析了其预测价值。
2008 年至 2011 年，我们在中国山西太原进行了一项 NHL 患者的前瞻性队列研究，共纳入 287 例 NHL 患者。采用对数秩检验比较 NHL 患者中高β2-M 水平与正常β2-M 水平之间的总生存（OS）。构建了三个包含国际预后指数（IPI）评分、β2-M 或 IPI 评分+β2-M 作为独立变量的标准 Cox 回归模型。使用时间依赖性接收者操作特征曲线方法和 C 指数来检验模型预测准确性随时间的变化趋势。
β2-M 值升高的 NHL 患者 OS 更差（p<0.001），死亡风险更高（HR=1.93，95%CI 1.37-2.77，p<0.001）。与仅包含 IPI 或β2-M 的模型相比，包含 IPI+β2-M 的模型的 C 指数有统计学显著差异（p<0.001）。
我们的研究结果表明血清β2-M 与 NHL 预后之间存在关联。β2-M 与 IPI 联合使用可能有助于提高 NHL 的预后准确性。
